background: clinical experiences have revealed that patients with breast cancer experience various sexual problems following their treatment. breast cancer negatively impacts the sexual life of the afflicted couples, and as a traumatic event can influence women’s psychosexual functioning and intimate relationship. this review focuses on sexuality after breast cancer and on a growing need for bi...

Breast cancer is the most common cancer in women that is driven by cross-talk with hormonal and cellular signaling pathways. The natural phytochemicals, due to broad-spectrum anti-inflammatory and anti-cancerous properties, present with novel opportunities for targeting breast cancer. Intake of citrus fruits is known to reduce the risk for incidence of breast cancer. Hence, we tested the effica...

The cancer stem cell (CSC) potency of a series structurally analogous Group 10-azadiphosphine metal complexes is reported. comprise 10 (Ni for 1, Pd 2, or Pt 3), an azadiphosphine ligand, and two chloride ligands. exhibit micromolar towards bulk breast cells CSCs cultured in monolayer systems. cytotoxicity the comparable to better than clinically used metallopharmaceuticals, cisplatin carboplat...

the male breast cancer (mbc) is a very rare neoplasm which accounts for 0.5-1% of the total cases of breast cancer. bilateral involvement is reported to occur in fewer than 2% of all the diagnosed cases of mbc, and synchronous tumors are very rare. because of its rarity, little is known about mbc etiology, its clinical findings and treatment. most patients present with a painless breast mass. t...

objective(s):leptin receptor (lepr) is a member of the class i cytokine receptor super-family that is known implicated in the initiation and progression of breast cancer. we have investigated the effect of q223r polymorphism on the breast cancer susceptibly in a sample of iranian subjects. materials and methods:we utilized a polymerase chain reaction (pcr) restriction fragment length polymorphi...

background post-mastectomy breast reconstruction is commonly performed in the united states with numerous options available to patients and providers. this study evaluated patient race and provider in prediction of patient satisfaction following post-mastectomy breast reconstruction. methods the patient satisfaction for women who underwent post mastectomy breast reconstruction at university of ...

IL-8 or CXCL8 has been associated with tumor angiogenesis, metastasis, and poor prognosis in breast cancer. Estrogen is crucial in breast carcinogenesis and tumor progression. Whether sex steroids affect IL-8 secretion of normal breast tissue or breast cancer is not known. Several cell types in a tissue secrete IL-8. Hence, regulatory mechanisms of IL-8 need to be investigated in whole tissue. ...

NEW DRUGS Perjeta, an Antibody For Metastatic Breast Cancer HER-2, a protein involved in normal cell growth, is found in increased amounts on some types of cancer cells, including some breast cancers. In HER-2–positive breast cancer, the increased amount of the HER-2 protein contributes to cancer cell growth and survival. About 20% of breast cancers have increased amounts of HER-2. The FDA rece...

Peripheral blood progenitor cells (PBPCs) are being used increasingly to provide hematopoietic support after intensive chemotherapy. However, many investigators have detected tumor cells contaminating PBPC collections. Methods that eliminate the tumor cells and spare the normal hematopoietic progenitor cells may improve the number of long-term, disease-free survivors after intensive chemotherap...

Recent studies revealed that micro RNA-10b (mir-10b) is highly expressed in metastatic breast cancer cells and positively regulates breast cancer cell migration and invasion through inhibition of HOXD10 target synthesis. In this study we designed anti-mir-10b molecules and combined them with poly L-lysine (PLL) to test the delivery effectiveness. An RNA molecule sequence exactly matching the ma...