studies have shown that patients who do not produce donor specific and / or panel reactive anti-hla antibodies have a longer graft survival. the purpose of this study was to evaluate the posttransplant humoral immune response towards hla-class i antigens and the measurement of the serum creatinine levels which are used in monitoring posttransplant function of kidney. serum samples from 132 rena...

titers were controlled after each ABO-incompatible transfusion using standard laboratory techniques. In the case of O/A recipientdonor blood group constellation we started adsorption of recipients’ Anti-A with one or two units of A2-RBCs followed by transfusion of A1-RBCs with a higher number of A-antigens per RBC. Using the technique of in vivo adsorption of isoagglutinins recipients’ anti-A o...

The mechanisms underlying latent-virus-mediated heterologous immunity, and subsequent transplant rejection, especially in the setting of T cell costimulation blockade, remain undetermined. To address this, we have utilized MHV68 to develop a rodent model of latent virus-induced heterologous alloimmunity. MHV68 infection was correlated with multimodal immune deviation, which included increased s...

Emotional reactions to anti-smoking advertising (e.g., fear, sadness, anger) may play an important role in promoting smoking-related attitudinal and behavioral change. Overall, 278 youth completed response ratings of 16 different elements of 50 anti-smoking ads made by tobacco-control agencies, tobacco companies, and pharmaceutical companies. Compared with tobacco-control ads, tobacco-company a...

The functional attributes of minor subpopulations of mouse thymus cells derived by bovine serum albumin density gradient centrifugation, cortisone treatment, or selective depletion by anti-TL or anti-theta treatment have been examined. A subpopulation derived in each fashion contains the cells required to evoke graft-versus-host reactions in neonatal F(1) hybrid recipients and to be stimulated ...

OBJECTIVE To investigate the effect of 6 weeks' pre-operative treatment with the angiotensin converting enzyme inhibitor, quinapril, on left ventricular function when measured 3 months after coronary artery bypass graft surgery and to examine the safety of such treatment. PATIENTS AND METHODS Patients (96) [86 males, 10 females; mean age 61 years] with chronic stable angina, on the waiting li...

BACKGROUND The risk of transmitting a hepatitis B virus (HBV) infection from donor kidneys with a past HBV serological profile may be negligible. Data on HBV transmission to kidney transplant recipients from donor organs that were anti-HBc/HBsAg in Italy has not been previously reported. Anti-HBc testing in cadaver organ donors has been mandatory in Italy since 2002, when anti-HBc determination...

A sequential, two-step procedure in which T-cell-depleted allogeneic stem cell transplantation is followed by treatment with donor lymphocyte infusion at 6 months can significantly reduce the risk and severity of graft-versus-host disease, with postponed induction of the beneficial graft-versus-leukemia effect. However, patients with high-risk leukemia have a substantial risk of relapse early a...

OBJECTIVES To investigate the frequency and risk factors affecting the incidence of post-transplantation glomerulonephritis (GN) and the impact of GN on the survival of the graft and the patient. PATIENTS AND METHODS Patients were classified based on histological findings into three groups. Graft survival was ascertained using the Kaplan-Meier method and significance calculated using log-rank...

There have been several advances in cardiac transplantation, but some problems remain. A major hurdle to long-term graft survival is the problem of chronic rejection or graft atherosclerosis which occurs in 30% to 60% of transplant patients within five years. In the Western world a significant imbalance between demand and supply for heart transplants exists; as a consequence, over 20% of patien...