background the evidence of rapid spread of multidrug resistant mycobacterium tuberculosis (mdr–tb) strains especially in high risk communities, persuade clinicians to find new drugs for this problem. β– lactams with few or no side effects has been reviewed as an alternative drugs for this issue. this study carried out to determine the effectiveness of amoxicillin–clavulanate in a group of irani...

The tuberculosis treatment control program is constrained by the outbreak of TB that resistant to anti-tuberculosis drugs (OAT), especially multidrug-resistant tuberculosis. Confirmation drug resistance really needs be done in each area considering there are variations phenotypes and genotypes region through laboratory tests such as molecular biology tests. Aim study determine prevalence Mycoba...

Multifocal tuberculosis is defined as the presence of lesions affecting at least two extrapulmonary sites, with or without pulmonary involvement. This retrospective study of 10 cases aims to investigate the clinical and evolutionary characteristics of multifocal tuberculosis. It included 41 cases with tuberculosis collected between 1999 and 2013. Ten patients had multifocal tuberculosis (24%): ...

BACKGROUND The aim of this study was to evaluate the diagnostic potential of immunohistochemistry using an antibody to the secreted mycobacterial antigen MPT64, in abdominal and lymph node tuberculosis. METHODS We used formalin-fixed histologically diagnosed abdominal tuberculosis (n = 33) and cervical tuberculous lymphadenitis (n = 120) biopsies. These were investigated using a combination o...

Tuberculosis (TB) is a disease with high risk of transmission and one the diseases whose cases continue to increase cause death worldwide. Until now, pulmonary tuberculosis has been difficult treat because patient's non-compliance taking anti-tuberculosis drugs (OAT). This study aims investigate factors associated adherence OAT in patients at Cut Meutia General Hospital. research an observation...

BACKGROUND Long duration of treatment, side-effects of currently used anti-tubercular drugs and emergence of drug-resistant forms of Mycobacterium tuberculosis (MTB) warrants the need to develop new drugs to tackle the scourge of tuberculosis (TB). Garlic is an edible plant reported to have anti-tubercular activity. However, previous researches on anti-tubercular effect of garlic were focused m...

Tuberculosis is a major infectious disease that globally causes the highest human mortality. From this aspect, this study was carried out to evaluate novel pharmacological activities/effects of artesunate and artemisinin causing anti-tubercular activity/effects against Mycobacterium tuberculosis (Mtb). The anti-Mtb activities/effects of artesunate and artemisinin were evaluated using different ...

In the light of three deaths due to liver failure secondary to anti-tuberculosis therapy at the Royal Free Hospital, we have reviewed the current literature, and asked--How common is liver dysfunction with anti-tuberculosis medications and how might it be prevented? Anti-tuberculosis chemotherapy is associated with abnormalities in liver function tests in 10-25% of patients. Clinical hepatitis ...