In this prospective study we examined the effect of prolonging cultures of peritoneal dialysis fluid to 21 days. The extended culture period did not lead to any new or clinically important findings, although late culture findings were obtained in a small number of cases. Prolonged culture of the effluent does not appear to be necessary, although it can lead to extended duration of antibiotic th...

BACKGROUND The optimal duration of antibiotic therapy for ventilator-associated tracheitis (VAT) has not been defined, which may result in unnecessarily prolonged courses of antibiotics. The primary objective of this study was to determine whether prolonged-course (≥7 days in duration) therapy for VAT was more protective against progression to hospital-acquired pneumonia (HAP) or ventilator-ass...

The seemingly inexorable spread of antibiotic resistance genes among microbial pathogens now threatens the long-term viability of our current antimicrobial therapy to treat severe bacterial infections such as sepsis. Antibiotic resistance is reaching a crisis situation in some bacterial pathogens where few therapeutic alternatives remain and pan-resistant strains are becoming more prevalent. No...

20-30% of gastric mucosa-associated lymphoid tissue (MALT) lymphoma associated with Helicobacter pylori do not regress after antibiotic therapy. Regression can be assessed only by extended follow-up. To assess whether t(11;18, q21;q21), which results in a chimeric transcript between the AP12 and MLT genes, predicts lymphoma resistance to antibiotic therapy, we screened for the fusion transcript...

BACKGROUND Urinary tract infections (UTIs) are a common reason for pediatric hospitalizations. OBJECTIVE To determine the effect of discordant antibiotic therapy (in vitro nonsusceptibility of the uropathogen to initial antibiotic) on clinical outcomes for children hospitalized for UTI. DESIGN/SETTING Multicenter retrospective cohort study in children aged 3 days to 18 years, hospitalized a...