نتایج جستجو برای: antibody deficiency
تعداد نتایج: 299696 فیلتر نتایج به سال:
The primary purpose of this systematic review was to produce an evidence-based review of the literature as a means of informing current clinical practice in the recognition, diagnosis and management of patients with suspected primary antibody deficiency. Randomized controlled trials (RCTs) were identified from a search of MEDLINE, EMBASE, The Cochrane Library, DARE (CRD website) and CINAHL by c...
Antibiotics have been common feed additives in poultry rations as growth promoters to improve performance via reducing burden of pathogens. However, it has been increasing pressure to reduce or even eliminate antibiotic usage in poultry feed due to the negative human health issues of antibiotic resistance. Safe broiler production without medication and vaccination was conducted at present study...
Most individuals carry two wild-type M alleles of the SERPINA1 gene which encodes a1-antitrypsin. 95% of severe deficiency of a1-antitrypsin is associated with the Z allele (Glu342Lys; denoted PiZZ in the homozygote), and with the retention and polymerisation of a1-antitrypsin within hepatocytes [1]. These polymers are contained within periodic acid–Schiff-positive, diastase-resistant inclusion...
an Italian multicentre study. Italian Society of Paediatric Gastroenterology and Hepatology (SIGEP) and “Club del Tenue” Working Groups on Coeliac Disease. Gut 1998;42:362–5. 4. Collin P, Maki M, Keyrilainen O, Hallstrom O, Reunala T, Pasternack A. Selective IgA deficiency and coeliac disease. Scand J Gastroenterol 1992; 27:367–71. 5. Hill PG, Forsyth JM, Semeraro D, Holmes GK. IgA antibodies t...
BACKGROUND Our aim was to investigate the prevalence and clinical relevance of inherited complement and antibody deficiency states in a large series of patients with various autoimmune rheumatologic diseases (ARD) with juvenile onset. METHODS A total number of 117 consecutive patients from 2 tertiary referral hospitals were included in the study. All patients underwent genetic screening for t...
BACKGROUND Although severe T cell immunodeficiency in DiGeorge anomaly is rare, previous studies of humoral function in these patients have found no antibody abnormalities but have not examined the response to polysaccharide antigens. Isolated cases of autoimmunity have been reported. Several patients with 22q11.2 deletion attending our immunology clinic suffered recurrent sinopulmonary infecti...
Specific antibody deficiency (SAD) with normal immunoglobulin and normal B cells is a primary immunodeficiency characterized by reduced ability to produce antibodies to specific antigens especially polysaccharides. OBJECTIVE To describe the characteristics of patients diagnosed with SAD emphasizing the association between primary immunodeficiency and allergic diseases. PATIENTS AND METHOD D...
Ig class-switch recombination (Ig-CSR) deficiencies are rare primary immunodeficiencies characterized by defective switched isotype (IgG/IgA/IgE) production. Depending on the molecular defect, defective Ig-CSR may also be associated with impaired somatic hypermutation (SHM) of the Ig V regions. Although the mechanisms underlying Ig-CSR and SHM in humans have been revealed (at least in part) by ...
Gennery A, Barge D, O’Sullivan J, et al. Arch Dis Child. 2002;86:422–425 Purpose of the Study. The aim of this study was to investigate humoral immunity, particularly antibody response to pneumococcal polysaccharide, and autoimmune anomalies in a cohort of patients with 22q11 deletion. Study Population. Thirty-two patients from the Newcastle, United Kingdom (UK) Pediatric Immunology Clinic were...
Vitamin K deficiency or administration of vitamin K antagonists results in the biosynthesis of abnormal des-’y-carboxy forms of the vitamin K-dependent proteins. Monoclonal antibody H-i 1 binds several vitamin K-dependent proteins at a determinant that includes the first two residues of ‘y-carboxyglutamic acid. Antibody H-i 1 binds fully carboxylated prothrombin and protein C in the presence of...
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