There is a need to search for new antifungals, especially the treatment of invasive Candida infections, caused mainly by C. albicans. These infections are steadily increasing at an alarming rate, mostly among immunocompromised patients. The newly synthesized compounds (3a–3k) were characterized physicochemical parameters and investigated antimicrobial activity using microdilution broth method e...

Medicinal plants are used in folk medicine to cure several human diseases. This work was designed evaluate the antioxidant and antimicrobial activities of different extracts Globularia alypum, Dittrichia viscosa, Juniperus oxycedrus, Retama sphaerocarpa. The total phenolic content (TPC), flavonoid (TFC), condensed tannin (CTC) were determined spectrophotometrically. activity tested using TAC, D...

Mycoses, candidiasis in particular, are relatively common opportunistic infections still characterized by an unacceptable high mortality rate. Furthermore, they are often complicated by resistance or refractoriness to the existing antimicrobial agents. In recent years new effective therapeutic and large-scale preventative strategies have been proposed by exploiting the identification of fungal ...

Management of oral candidosis, most frequently caused by Candida albicans, is limited due to the relatively low number of antifungal drugs and the emergence of antifungal tolerance. In this study, the antifungal activity of a range of commercial essential oils, two terpenes, chlorhexidine and triclosan was evaluated against C. albicans in planktonic and biofilm form. In addition, cytotoxicity o...

By LEONA CAROLINE, FRED ROSNER AND PHILIP J. KOZINN T RANSFERRIN OR SIDEROPHILIN is the iron binding protein of human plasma and has the electrophoretic mobility of a beta-l-globulin. Normally only about one third of the transferrin is saturated with iron.1 In 1946, Schade and Caroline2 demonstrated the bacteriostatic effect of transferrin. This in vitro antimicrobial power is depressed by free...

IL-12 is both required and prognostic for Th1 development in mice with Candida albicans infection. To delineate further the physiologic role of IL-12 in antifungal immunity, mice deficient for this cytokine were assessed for susceptibility to C. albicans infections, and for parameters of innate and adaptive immunity. IL-12-deficient mice were highly susceptible to gastrointestinal infection or ...

Lactobacilli, the predominant vaginal microorganisms in healthy premenopausal women, control other members of the vaginal microflora and thus protect against bacterial vaginosis and urinary tract infections. It has been claimed that some lactobacilli are also protective against Candida vaginitis. Little is known, however, about the mechanisms by which these lactobacilli can control vaginal popu...

The aim of the present study was to evaluate chitosan as a vaginal mucoadhesive gel base for econazole nitrate and miconazole nitrate. To this aim, different types of chitosan with different molecular masses and viscosity properties [low molecular mass chitosan (viscosity: 20,000 mPa s), medium molecular mass chitosan (viscosity: 200,000 mPa s), high molecular mass chitosan (viscosity: 800,000 ...