نتایج جستجو برای: anticonvulsant effect
تعداد نتایج: 1644634 فیلتر نتایج به سال:
Benzodiazepines are used to treat the anxiety associated with cocaine withdrawal, as well as cocaine-induced seizures. Since cocaine exposure was shown to affect BZ binding density, abuse liability, subjective hypnotic actions and seizure susceptibility, we assessed whether chronic cocaine alters diazepam's anxiolytic and anticonvulsant actions. Changes in GABA(A) receptor subunit protein expre...
PURPOSE Serotonin is a key regulatory neurotransmitter in the CNS which plays an important role in seizure through different receptors, especially the 5HT1A subtype. The role of sertraline through the 5HT1A receptor and nitric oxide interaction on the PTZ-induced seizure threshold was investigated in this study. METHOD In this study, 70 white male mice were randomly divided into 10 groups inc...
Artocarpus heterophyllus Lam. (Jackfruit) is traditionally used as anticonvulsant. The aqueous and methanol extracts of leaves of Artocarpus heterophyllus Lam. was evaluated for anticonvulsant activity by using Maximal electroshock (MES) and Strychnine induced convulsions models on Swiss albino mice. The methanol extracts of leaves of Artocarpus heterophyllus Lam. were found to be more signific...
In the present study, a series of 4-(4-substituted aryl) semicarbazones were synthesized from substituted anilines and subsequently evaluated for their anticonvulsant activities. The anticonvulsant activities were established by the anticonvulsant drug development (ADD) programme NIH, USA using experimental animal, adult male FCM mice (20-25 g) and adult Sprague-Dawley rats (100-150 g) and scre...
A series of aroxyacetamides and aroxyethylamines were prepared and evaluated for anticonvulsant activity in the maximal electroshock seizure (MES) and subcutaneous pentylenetetrazole seizure threshold (ScMet) assays and for neurotoxicity (TOX). Most of them exhibited anticonvulsant activity in the MES screen (mice, i.p.) in the doses up to 300 mg/kg b.w. The most active compound was XVI, which ...
Non-selective benzodiazepines, such as diazepam, interact with equivalent affinity and agonist efficacy at GABA(A) receptors containing either an alpha1, alpha2, alpha3 or alpha5 subunit. However, which of these particular subtypes are responsible for the anticonvulsant effects of diazepam remains uncertain. In the present study, we examined the ability of diazepam to reduce pentylenetetrazoLe ...
background: there have been some reports about the possible n-methyl-d-aspartate (nmda) antagonist activity of guaifenesin. as drugs with a similar structure to guaifenesin (i.e. felbamate) and those with nmda antagonist activity have been clinically used as anticonvulsants, the aim of this study was to determine whether guaifenesin has an anticonvulsant effect in an animal model of seizure. me...
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