Alcohol withdrawal seizures are one major complication during detoxification treatment of alcohol dependent patients. Anticonvulsive pharmaceutical treatment can be administered but is associated with side-effects like nausea or hyponatriemia. Recent studies have identified different biomarkers that have been associated with the risk of alcohol withdrawal seizures. The aminoacid homocysteine as...

A number of orthopedic injuries can occur during epileptic seizures. Anterior shoulder dislocation is one such orthopedic injury that is quite rare. The shoulder dislocation may injure the brachial plexus. Besides seizures, the nerves can also be damaged by anticonvulsive therapy. Muscle wasting following a seizure can misguide a clinician to investigate only neural or muscular pathologies. We ...

a new method was developed for the spectral resolution by further determination of three- and  four-component  mixtures  of  drugs in urine samples through  the complementary application of multivariate curve resolution-alternating least squares with correlation  constraint. in the current study, a simple method was proposed to construct a calibration set for the mixture of drugs in the presenc...

The thionamide drugs, i.e. carbimazole and its metabolite methimazole (MMI), andpropylthiouracil (PTU) have extensively been used in the management of various forms ofhyperthyroidism over the past eight decades. This review aims to summarize different aspectsof these outstanding medications. Thionamides have shown their own acceptable efficacy andeven safety profiles in ...

In the practice of neurosurgical operations the convulsions occasionally elicited during cortical manipulations or produced by electrical stimulations may sometimes be difficult to control, and may give rise in some cases to dangerous convulsive states that may even end fatally. Barbiturates and other common drugs may fail to stop such convulsions quickly, as we have observed in some of our cas...

The study was designed to investigate the effect of various concentrations of cannabidiol (CBD) in rats with chronic epilepsy. The chronic epilepsy rat model was prepared by intraperitoneally injecting pentylenetetrazole to the rats pre-treated with CBD (10, 20 and 50 mg/kg) for 28 consecutive days. Behavioral measurements of convulsion following pentylenetetrazole treatment and morphological c...

A 21 year-old boy was seen by one of us (O.V.) 6 days after he had suffered from a convulsive attack with loss of consciousness. He had previously been treated with anticonvulsive drugs for similar episodes without improvement. A striking clinical finding was an irregular bradycardia, with a heart rate of 20 a minute. The blood pressure was 110/60 mm. Hg. The venous pulse showed independent "a"...

Diazepam (DZP) and phenobarbital (PB) are extensively used as first and second line drugs to treat acute seizures in neonates and their actions are thought to be mediated by increasing the actions of GABAergic signals. Yet, their efficacy is variable with occasional failure or even aggravation of recurrent seizures questioning whether other mechanisms are not involved in their actions. We have ...