Introduction: In this study the antidepressant effect of a new morpholino betalactam composition, 1-(3- morpholinopropyl)-4-(naphthalene-2-yl)-3-phenoxyazetidin-2-one (EB9) administered at three doses, was investigated in an animal model of depression. The CNS stimulant, muscle coordination and toxic effects of this compound were also tested. Methods: Morpholino betalactam at 10, 15 and 20 ...

Antidepressant pharmacotherapy is to date the most often used treatment for depression, but the exact mechanism of action underlying its therapeutic effect is still unclear. Many theories have been put forward to account for depression, as well as antidepressant activity, but none of them is exhaustive. Neuroimmune endocrine impairment is found in depressed patients; high levels of circulating ...

general population surveys often report that only a small proportion of individuals with common mental disorders seek mental health treatment, suggesting a high level of unmet need for mental health care in the community. in recent years, however, the number of adults in industrialized countries who are treated with antidepressant medications has dramatically increased. this paper reviews the p...

FOR HKMA Antidepressant drugs have unique toxicities that are based on their pharmacology and determine their specific treatment. There are currently 4 classes of antidepressant drugs: monoamine oxidase inhibitors, cyclic antidepressants, selective serotonin reuptake inhibitors, and the atypical antidepressants which include a variety of other drugs. The selective serotonin reuptake inhibitors ...