Studies establishing the use of new antidepressants often rely simply on proving efficacy of a new compound, comparing against placebo and single compound. The advent of large online databases in which patients themselves rate drugs allows for a new Big Data-driven approach to compare the efficacy and patient satisfaction with sample sizes exceeding previous studies. Exemplifying this approach ...

We developed and tested a new putative analgesic cream, based on the anticonvulsant phenytoin in patients suffering from treatment refractory neuropathic pain. The use of commercial topical analgesics is not widespread due to the facts that capsaicin creams or patches can give rise to side effects, such as burning, and analgesic patches (e.g., lidocaine 5% patches) have complex handling, especi...

Twenty five patients of endogenous depression fulfilling Feighner's criteria were selected for this study. It was found that the patients who improved with methylamphetamine responded to imipramine and those who did not improve with methylamphetamine improved with amitriptyline.

BACKGROUND This open, multicentre, observational survey investigated how physicians diagnose neuropathic pain (NeP) by applying the Leeds Assessment of Neuropathic Symptoms and Signs (LANSS) scale, and how neuropathic pain conditions are managed in daily practice in Belgium. METHODS Physicians were asked to complete the Leeds Assessment of Neuropathic Symptoms and Signs (LANSS) scale for diag...

BACKGROUND In the period 1990-2006, strong and almost equivalent increases in sales figures of selective serotonin re-uptake inhibitors (SSRIs) were observed in all Nordic countries. The sales figures of tricyclic antidepressants (TCAs) dropped in Norway and Sweden in the nineties. After 2000, sales figures of TCAs have been almost constant in all Nordic countries. The potentially toxic effect ...

Selective serotonin reuptake inhibitors (SSRIs) have become the most popular antidepressants over the last decade, largely because they have a better side effect profile than the medications that were widely used previously, the tricyclic antidepressants (TCAs) and the monoamine oxidase inhibitors (MAOIs). The SSRIs mostly have one main mechanism of action, inhibition of serotonin reuptake. A f...

Two-dimensional nuclear magnetic resonance (2D NMR) spectroscopy has been used to assign 13C spectra of the tricyclic antidepressants imipramine and chlorimipramine . The 2DINADEQUATE method was used to unambiguously assign the aromatic spectral region for the former compound. Errors in previous literature assignments based on 1D methods were corrected. For chlorimipramine the pitfalls of class...

ROTH, K. A. AND R. J. KATZ. Further studies on a novel animal model of depression: Therapeutic effects of a tricyclic antidepressant. NEUROSCI. BIOBEHAV. REV. 5(2) 253-258, 1981.--We have previously shown that rats given stress before open field testing have elevated activity in comparison with unstressed rats. This acute behavioral response may be eliminated by chronic stress and restored by p...

Plasma levels of tricyclic antidepressant drugs vary considerably between individuals receiving the same amount of drug. The bearing of this variation on the occurrence of subjective side effects was investigated in 40 psychiatric inpatients with depressive disorders. Plasma levels were determined before and during four weeks of treatment with nortriptyline 50 mg. three times a day and patients...