Itraconazole is a recently developed triazole antifungal agent that inhibits cell membrane sterol biosynthesis. Itraconazole, in a dose-dependent manner, enhanced intracellular accumulation of daunorubicin and reversed the drug resistance in murine leukemia P388/ADR cells. In addition, itraconazole corrected the altered plasma membrane potentials of P388/ADR cells. The concentrations of itracon...

For filamentous fungi (moulds), species-specific interpretive breakpoints and epidemiological cut-off values (ECVs) have only been proposed for a limited number of fungal species-antifungal agent combinations, with the result that clinical breakpoints are lacking for most emerging mould pathogens. In the current study, we have compiled minimum inhibitory concentration (MIC) data for 4869 clinic...

Among various pathogenic fungi, Candida species is the only pathogen capable of causing wide spectrum of clinical manifestations ranging from mucocutaneous overgrowth to disseminated infections. Although Candida albicans is considered as the most pervasive pathogenic species, recent studies from various parts of the world have documented the emergence of non albicans Candida (NAC) spp. The Cand...

Anincreasing number of patients with marked immunosuppression as a result of transplantation, cancer and infection with Hiy has led to the increased, and widespread use of systemic antifungal agents.1} Currently available treatment is limited to 5-fluorocytosine, amphotericin B and azoles such as fluconazole and itraconazole. However, various problems effect the use of these agents. Among the m...

Species of Candida and Aspergillus remain the most common causes of invasive fungal infections, but other yeasts and filamentous fungi are emerging as significant pathogens. Opportunistic yeast-like fungi and moulds such as Zygomycetes, Fusarium spp. and Scedosporium spp. are increasingly being recognised in patient groups such as those with leukaemia and in bone marrow transplant recipients. R...

Fresh flowers of Allamanda Cathartica Linn. were collected and was extracted with 90% methanol under reflux. The alcoholic extract was concentrated in vacuo and the aqueous concentrate was fractionated with benzene, peroxide free diethylether and ethylacetate successively. The ethyl acetate fraction was concentrated in vacuo and left in an ice chest for a few days. The yellow solid obtained, a ...

Background: Plants have various defense mechanisms such as production of antimicrobial peptides, particularly pathogenesis related proteins (PR proteins). PR10 family is an essential member of this group, with antifungal, antibacterial and antiviral activities.Objective: The goal of this study is to assess the antifungal activity of maize PR10 against some of fungal phytopathogens.M...

Species of Candida and Aspergillus remain the most common causes of invasive fungal infections, but other yeasts and filamentous fungi are emerging as significant pathogens. Opportunistic yeast-like fungi and moulds such as Zygomycetes, Fusarium spp. and Scedosporium spp. are increasingly being recognised in patient groups such as those with leukaemia and in bone marrow transplant recipients. R...

Onychomycosis is a fungal nail infection which is relatively common and difficult to treat. Treatment modalities include nail avulsion, surgical debridement and combination therapy with oral and topical antifungal drugs. In spite of a host of available drugs, clinical cure rates remain discouraging. Drug toxicities, prolonged regimens, lack of patient compliance, and high keratin affinity of dr...

OBJECTIVES The in vitro antifungal activity of posaconazole was compared with that of fluconazole and amphotericin B. MATERIALS AND METHODS A microdilution method (M27-A2) was used with 331 clinical yeast isolates. RESULTS The geometric mean MICs of posaconazole, fluconazole and amphotericin B were 0.16, 0.91 and 0.15 mg/L, respectively. Posaconazole was markedly more active than fluconazol...