F ungal pathogens are notoriously difficult to treat because of antifungal drug toxicity and drug resistance, and the limited armamentarium (1). Some drug classes inhibit fungal growth but do not efficiently eliminate pathogens, and there is a pressing need for advances in antifungal therapy. The problem is especially acute in the immunocompromised. In a recent issue of PNAS, Cowen et al. (2) d...

Purpose: To evaluate the efficacy of different modalities of antifungal agents in the treatment, clinical features and therapeutic outcome of fungal keratitis Design: Retrospective observational case series. Methods: The study reviewed 251 eyes of 246 patients treated for moderate and severe fungal keratitis in the period from 2010 to 2015. The diagnosis of fungal keratitis based on the clinica...

The antimicrobial efficacy of methanol and water extracts of seeds of the plant Swietenia macrophylla (Family: Meliaceae) was evaluated against selected pathogenic bacterial strains (Bacillus cereus MTCC 430, Klebsiella penumoniae MTCC 109, Pseudomonas aeruginosa MTCC 424, Escherichia  coli MTCC 443, Staphylococcus aureus MTCC 96, Salmonella typhimurium MTCC 98, Micrococcus luteus MTCC 106...

Invasive fungal infections caused by drug-resistant organisms are an emerging threat to heavily immunosuppressed patients with hematological malignancies. Modern early antifungal treatment strategies, such as prophylaxis and empirical and preemptive therapy, result in long-term exposure to antifungal agents, which is a major driving force for the development of resistance. The extended use of c...

Invasive fungal infections are difficult to eradicate especially in immuno-compromised host. Amphotericin B and voriconazole have been the mainstay of treatment but both have significant toxicity. Caspofungin belongs to a new class of antifungal agents, the echinocandins. It acts on the fungal cell wall by selective inhibition of beta-(1,3)-D-glucan syntheses, which is not present in mammalian ...

objective(s): the aim of the present study was to prepare, characterize, and evaluate solid lipid nanoparticles (slns) containing zataria multiflora essential oil (zeo). materials and methods: in this study, z. multiflora essential oil-loaded solid lipid nanoparticles (ze-slns) were prepared to improve its efficiency in controlling some fungal pathogens. slns containing z. multiflora essential ...

Cutaneous fungal infections remain a clinical problem. Among fungi, dermatophyte molds are the major cause of various type of Tinea. These infections are still difficult to manage and some of the antifungal agent are poorly tolerated or have been associated with emergence of resistance. The traditional methods, especially the use of medicinal plants place an imperative role to cover the basic h...

Cutaneous fungal infections remain a clinical problem. Among fungi, dermatophyte molds are the major cause of various type of Tinea. These infections are still difficult to manage and some of the antifungal agent are poorly tolerated or have been associated with emergence of resistance. The traditional methods, especially the use of medicinal plants place an imperative role to cover the basic h...