In previous studies, the relaxant, anticholinergic (functional antagonism) antihistaminic, effects of Nigella sativa have been demonstrated on guinea-pig tracheal chains. In the present study, the prophylactic effect of boiled extract of N. sativa on asthmatic disease was examined. Twenty-nine asthmatic adults were randomly divided into control group (14 patients) and study group (15 patients),...

BACKGROUND Stilbene-based compounds show antitumoral, antioxidant, antihistaminic, anti-inflammatory and antimicrobial activities. Here, we evaluated the effect of the trans-resveratrol analogs, pterostilbene, piceatannol, polydatin and oxyresveratrol, against Leishmania amazonensis. METHODOLOGY/PRINCIPAL FINDINGS Our results demonstrated a low murine macrophage cytotoxicity of all four analo...

Plants have been the main source of therapeutic agents in world’s most ancient system medicine, Ayurveda. Nimb (also known as Margosa tree) is one commonly used plants Ayurveda for management a large number ailments. It member Meliaceae family, found India, Africa and America. has exclusively by mankind to treat various diseases since even before availability manuscripts that recorded beginning...

Case report A 32-year-old woman was referred to the emergency department because she developed a skin eruption, pruritis and frisson which have occurred four hours after the intake of 200mg of celecoxib for inflammatory back pain. Physical examination revealed generalized urticaria which was thought to be induced by celecoxib. Therefore, she was prescribed corticosteroid therapy and antihistami...

Experiments were carried on in the Wistar rats having self-stimulation (SS) electrodes implanted chronically in substantia nigra-ventral tegmental area (SN-VTA) to examine whether modulations of GABAergic, serotonergic, histaminergic, dopaminergic, and glucocorticoid neuronal receptor functions will affect or not the brain reward system and the SS behaviour. The modulators are the wellknown dru...

most satisfactory and which disorders can be improved by their administration. Recently the equipotent doses of the commonly available preparations have been determined (Bain, Broadbent and Warin, 1949, and Bain, 1949). In this work weals have been induced in the skin of man by intradermal injections of histamine. The size of the weal is less if the injection is made at a suitable interval afte...