Trypanosomiasis and leishmaniasis are a group of neglected parasitic diseases caused by several species parasites belonging to the family Trypansomatida. The present study investigated antitrypanosomal antileishmanial activity chalcones flavanones from Polygonum salicifolium, which grows in wetlands Iraq. phytochemical evaluation plant yielded two chalcones, 2′,4′-dimethoxy-6′-hydroxychalcone 2...

Previous studies reported antiprotozoal activities of Sapindus saponaria L. The aim of this work was the evaluation of antileishmanial activity and mechanism of action of extract and fractions of S. saponaria L. Hydroethanolic extract (EHA) obtained from fruit pericarps was fractionated using solid-phase extraction in a reversed phase, resulting in fractions enriched with saponins (SAP fraction...

Twelve hybrids derived from triclosan were obtained via Williamson etherification of O-triclosan alkyl bromide plus chalcone and O-coumarin or O-chromone alkyl bromide plus triclosan, respectively. Structures of the products were elucidated by spectroscopic analysis. The synthesized compounds were evaluated for antileishmanial activity against L. (V) panamensis amastigotes. Cytotoxic activity w...