The antioxidant and hepatoprotective effects of Heterotheca inuloides have been reported before, nevertheless its use as a possible chemopreventive agent has not been documented. The aim of this study was to evaluate the mutagenic and antimutagenic activities of H. inuloides extracts using the Ames test. Both, the methanolic and acetonic extracts, were mutagenic in the TA98 but not in TA100 or ...

Purple rice (Oryza sativa L. var. indica) cv. Kum Doisaket is cultivated in northern Thailand. This study evaluated the mutagenic and antimutagenic properties of hydrophilic and lipophilic components of purple rice using the Ames test. The seed and hull of purple rice were extracted with hexane, methanol, ethanol, and water. The methanol extracts had the highest amounts of phenolic acids and fl...

The present study was designed to evaluate the antimutagenic potential of ripe Aegle marmelos fruit, using micronucleus and chromosomal aberration assay in mouse bone marrow. The antimutagenic effect of 50% methanolic extract of ripe Aegle marmelos fruit was assessed using cyclophosphamide induced micronuclei (MN) formation and chromosomal aberration (CA) in mouse. The animals were pre-treated ...

The chalcone (E)-1-(2-hydroxyphenyl)-3-(4-methylphenyl)-prop-2-en-1-one), or 2HMC, displays antileishmanial, antimalarial, and antioxidant activities. The aim of this study was to investigate the cytotoxic, genotoxic, mutagenic, and protective effects of 2HMC using the Ames mutagenicity test, the mouse bone marrow micronucleus test, and the comet assay in mice. In the assessment using the Ames ...

peganum harmala is a plant that is traditionally used as an analgesic, anti-inflammatory, antibacterial, antioxidant, anti-helmintic, and antimutagenic agent. moreover, it is used to treat a variety of human ailments, including depression. this study was conducted to investigate the antidiabetic activity of hydro alcoholic extract of this herb. a hydro alcoholic extract from seeds of this herb ...

Until recently, it was believed that the effects of probiotics are limited to a certain range specific effects, but more and studies indicate their action on host organism is complex systemic. Such interference in regulation various pathways organism. Systemic effect does not mean sum many minor impacts precisely targeted impact most sensitive points or metabolic pathways. That allows achieve s...

We have determined the abilities of (E)-ferulic acid, (E)-p-coumaric acid and (E,E)-5-5-dehydrodiferulic acid to protect against different types of mutation in a simple bacterial model. These antimutagenic properties were compared with those of the related compound curcumin, and also with those of an extract containing hydroxycinnamic acids obtained by the saponification of the cell walls of wh...

The antimutagenic and antioxidant properties of various phenolic fractions obtained from Andean purple corn were examined by the Ames test and the DPPH antiradical assay. An anthocyanin-rich water fraction (WF) and an ethyl acetate fraction (EAF) showed a dose-dependent antimutagenic behavior against the food mutagen Trp-P-1 with IC50 values of 321.7 +/- 21.36 and 95.2 +/- 10.95 microg of chlor...