Antioxidants inhibit the rat liver microsomal mixed-function-oxidase-catalysed hydroxylation of benzo[a]pyrene. These antioxidants also decrease the formation of mutagenic products from benzo[a]pyrene as judged by the Ames bacterial-mutagenicity assay [B.N. Ames, J. McCann & E. Yamazaki (1975) Mutat. Res. 31, 347-364]. It is suggested that antioxidants exert their protective effect against canc...

3 Introduction 3 Pathophysiological features of reperfusion injury 4 Metabolic changes in myocardial ischemia-reperfusion 7 Oxidative stress in myocardial ischemia-reperfusion 9 Types of antioxidants 11 Role of antioxidants in myocardial ischemia-reperfusion injury 12 Hypothesis 15 Hypothesis 1: Xanthine oxidase inhibitor can protect against myocardial ischemia-reperfusion injury. 15 Hypothesis...

background: prepubertal varicocele has the most devastating effects on the testes. oxidative stress is the major cause leading to infertility in varicocele. the antioxidant properties of flaxseed (fs) treatment in some oxidative diseases have been reported. objective: this study aimed to evaluate the antioxidant effect of fs in prepubertal rats with experimental varicocele. materials and method...

background: leishmania is a significant health problem in many parts of the world. tumor necrosis factor (tnf) plays an essential role in leishmania major infections. objective: to study the pro-inflammatory cytokines and antioxidants in four groups of cutaneous leishmaniasis patients. methods: 39 patients were divided into four groups of: 1) active (acute phase of treatment); 2) non-healing (r...

conclusions the results of the present study indicate the protective effects of melissa officinalis on some sperm parameters and spermatogenesis quality in rats exposed to lead. background some medicinal plants with their antioxidant properties have protective effects on sperm parameters and neutralize the harmful effects of lead exposure. objectives the present study aimed to determine the eff...

allergic asthma is the most common acute inflammatory airway disorder and their incidence population has exploded in the last years, being estimated that over 300 million people worldwide have the condition. here, we present a brief overview of relationship of allergic asthma with diet and food intake. several studies have shown that most asthma cases are due to an allergic immune response to e...

All biological systems functioning in aerobic conditions are exposed to reactive oxygen species (ROS), a class of oxygen metabolites that are highly active in terms of oxidative modification of proteins, lipids, and DNA. ROS has been found to contribute to aging and quite a number of chronic diseases including diabetes, cardiovascular diseases, neurological disorders, and cancer. Thus, reducing...