Schizophrenia is a serious mental disorder that affects social function of patients. Clinical characteristics of schizophrenia are early onset age and prolonged disease course. With the extensive application of antipsychotics, there are significant improvements in the remission rate of psychotic symptoms such as impaired social function in schizophrenic patients. However, in recent years, disru...

Pneumatosis intestinalis (PI) is an uncommon but important condition characterized by the accumulation of gases in the submucosa or subserosa of the gastrointestinal wall. The clinical course of PI represents a wide spectrum of conditions and outcomes that range from benign to life-threatening. Although controversy exists about the exact cause of PI, mucosal integrity, intraluminal pressure, ga...

BACKGROUND Psychotic depression is a clinical subtype of major depressive disorder. A number of clinical studies have demonstrated the efficacy of the combination of an antidepressant (for example, a tricyclic antidepressant or selective serotonin reuptake inhibitor (SSRI)) and an atypical antipsychotic or electroconvulsive therapy in treating psychotic depression. In some cases, the clinician ...

Objectives To examine the relation between antipsychotic drugs and myocarditis and cardiomyopathy. Design Data mining using bayesian statistics implemented in a neural network architecture. Setting International database on adverse drug reactions run by the World Health Organization programme for international drug monitoring. Main outcome measures Reports mentioning antipsychotic drugs, cardio...

BACKGROUND Relapse prevention with antipsychotic drugs compared with placebo in patients with schizophrenia has not been sufficiently addressed by previous systematic reviews. We aimed to assess the association between such drugs and various outcomes in patients with schizophrenia to resolve controversial issues. METHODS We searched the Cochrane Schizophrenia Group's specialised register for ...

objective: tardive dyskinesia (td), is one of the important problems of the patients with schizophrenia. the emergence of these side effects depends on so many factors such as the patients' age and the duration of antipsychotic treatment. by discovering new drugs (atypical), there has been an outstanding decrease in the emergence of these side effects. the present study investigates the symptom...

Recent studies indicate that levels of presynaptic proteins are altered in the post-mortem brain in schizophrenia. In particular, the hippocampus exhibits reduced levels of synaptophysin and the SNARE protein SNAP-25. The effects of treatment with antipsychotic drugs on levels of SNAP-25 in the hippocampus remains unknown. To determine the effects of typical antipsychotic drugs on levels of syn...

The present prospective study is conducted to determine the prophylactic value of antiparkinsonian drug (A.P.) at the time of initiation of antipsychotic therapy. Seventy patients were selected who fulfilled the selection criteria. Thirty five patients received antipsychotic drugs alone (Group A), while another thirty five patients received A.P. drugs concurrently with antipsychotic drugs (Grou...

The introduction of atypical antipsychotic drugs (AAPDs), or second-generation antipsychotics, with clozapine as the prototype, has largely changed the clinicians' attitudes toward the treatment of mental illnesses including, but not limited to schizophrenia. Initially, there was optimism that AAPDs would be superior over typical antipsychotic drugs (TAPDs), or first-generation antipsychotic dr...

OBJECTIVES To examine the relation between antipsychotic drugs and myocarditis and cardiomyopathy. DESIGN Data mining using bayesian statistics implemented in a neural network architecture. SETTING International database on adverse drug reactions run by the World Health Organization programme for international drug monitoring. MAIN OUTCOME MEASURES Reports mentioning antipsychotic drugs, ...