High-pressure microfluidic systems exhibit favorable capacity to enhance mixing quality compared conventional macroscale liquid systems. These conditions are very interesting for the preparation of fluorescent organic nanoparticles by supercritical antisolvent process. In this work, fundamental mechanisms process (µSAS) including thermodynamics, hydrodynamics, nucleation/growth phenomena, inves...

The design of crystallization processes becomes more complicated when mixing affects the final crystal product quality (e.g., crystal size distribution and polymorphic form). Such mixing effects are more apparent in antisolvent and reactive crystallizations, which involve the blending of different fluids, and in large-scale crystallizers, where homogeneity cannot be easily achieved. In this pap...

Micronization of minocycline hydrochloride dissolved in ethanol and with supercritical carbon dioxide as antisolvent was successfully performed using a recently built SAS apparatus. Amorphous particles of minocycline ranging from 100 to 1000 nm (depending on the operating conditions) were obtained. The mean particle size and the particle size distribution were determined by Dynamic Light Scatte...

The purpose of this study was to find an artificial neural networks model for determining major factors impacting the stability of an acetaminophen nanosuspansion that was prepared using nanoprecipitation in microfluidic reactors. Four variables, namely concentration of surfactant, solvent and antisolvent flow rate and solvent temperature were used as input variables and time of sedimentation o...

BACKGROUND Drug nanosuspensions are very promising for enhancing the dissolution and bioavailability of drugs that are poorly soluble in water. However, the poor stability of nanosuspensions, reflected in particle growth, aggregation/agglomeration, and change in crystallinity state greatly limits their applications. Solidification of nanosuspensions is an ideal strategy for addressing this prob...

To elucidate the correlation between enhanced biogas production and changed physico-chemical properties of methanogenic granules after low strength ultrasonication, in this study, the effects of low strength ultrasonication on the settling velocity, permeability, porosity, and fluid collection efficiency of the methanogenic granules were investigated. In addition, their morphological changes we...

Introduction Infection is one of the most important causes of joint implant failure. The polymerase chain reaction (PCR) is a sensitive way to test for bacteria, but most PCR procedures take too long to provide results during a revision arthroplasty operation. For example, we have described the sensitivity and specificity of real-time PCR combined with ultrasonication of retrieved implants to d...

AIM To evaluate the effect on physical properties of Mineral Trioxide Aggregate (MTA) of using direct hand compaction during placement and when using hand compaction with indirect ultrasonic activation with different application times. METHODS One hundred acrylic canals were obturated in 3 increments with MTA in sample sizes of 10. One group was obturated by hand with an endodontic plugger an...