We report a patient with a mass in the right atrium which led to pulmonary embolism. Postoperatively the mass was identified as a tuberculoma and it was culture-positive for Mycobacterium tuberculosis. Patient responded to modified antitubercular treatment and discharged from hospital in satisfactory condition.

A series of diamines and amino alcohols derived from 1-dodecanol, 1-tetradecanol, 1,2-dodecanediol and 1,2-tetradecanediol were synthesized and tested for their antitubercular activity. Compounds 3, 8 and 9 were found to be the most active (MIC of 6.25 microg/mL). Nine other compounds displayed activity against Mycobacterium tuberculosis, with a MIC of 12.5 microg/mL.

AIMS To study perfusion characteristics of intracranial tuberculomas and analyze changes with anti tubercular treatment. MATERIALS AND METHODS Nineteen patients of histologically proven intracranial tuberculomas were included in the study of which 9 were not on antitubercular treatment and ten were on antitubercular treatment (6 patients on treatment for less than 2 months and 4 were more tha...

Tuberculosis (TB) remains a common disease but has atypical presentations. The association of TB with immune thrombocytopenia is not well recognised. purpose this case report to highlight the rare complication secondary in an endemic country like India. Prompt initiation antitubercular therapy and steroids only reduces need for unnecessary transfusions also hastens recovery patient. Knowledge a...

The action of salicylhydroxamic acid and its halogen derivatives against tuberculosis, fungi, trypanosomae, and the biosynthesis of cholesterol are described. Their hypoglycemic and phospholipid lowering actions are also mentioned. The author suggested, in 1948, the use of salicylhydroxamic acid I (X = Y = Z = R = H)—called SH—as an antitubercular agent [26]. The suggestion was based on the hyp...

Novel drugs to treat tuberculosis are required and the identification of potential targets is important. Piperidinols have been identified as potential antimycobacterial agents (MIC < 5 μg/mL), which also inhibit mycobacterial arylamine N-acetyltransferase (NAT), an enzyme essential for mycobacterial survival inside macrophages. The NAT inhibition involves a prodrug-like mechanism in which acti...