نتایج جستجو برای: antiviral immunity

تعداد نتایج: 114366  

2015
Chean Ring Leong Hiroyuki Oshiumi Takayuki Suzuki Misako Matsumoto Tsukasa Seya

Cellular innate immune system recognizing pathogen infection is critical for the host defense against viruses. Hepatitis B virus (HBV) is a DNA virus with a unique life cycle whereby the DNA and RNA intermediates present at different phases. However, it is still unclear whether the viral DNA or RNA templates are recognized by the pattern-recognition receptors (PRRs) to trigger host antiviral im...

Journal: :The Journal of Experimental Medicine 1937
Philip D. McMaster John G. Kidd

An antiviral principle is elaborated within the regional lymph nodes draining skin into which vaccinia is injected. The immunity conferred by clinical Jennerian vaccination may be largely of lymph node origin.

2016
James D. Porter Jennifer Watson Lee R. Roberts Simren K. Gill Helen Groves Jaideep Dhariwal Mark H. Almond Ernie Wong Ross P. Walton Lyn H. Jones John Tregoning Iain Kilty Sebastian L. Johnston Michael R. Edwards

BACKGROUND Exacerbations of asthma and COPD are triggered by rhinoviruses. Uncontrolled inflammatory pathways, pathogenic bacterial burden and impaired antiviral immunity are thought to be important factors in disease severity and duration. Macrolides including azithromycin are often used to treat the above diseases, but exhibit variable levels of efficacy. Inhaled corticosteroids are also read...

2016
Wenchun Fan Mengge Wu Suhong Qian Yun Zhou Huanchun Chen Xiangmin Li Ping Qian

The members of tripartite-motif containing (TRIM) protein participate in various cellular processes and play an important role in host antiviral function. TRIM proteins exert their antiviral activity either directly by degrading viral proteins through their E3 ligase activity, or indirectly by promoting host innate immunity. This study demonstrated for the first time that TRIM52 is a novel anti...

Journal: :Cellular Physiology and Biochemistry 2018

Journal: :Acta Crystallographica Section A Foundations and Advances 2014

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