OBJECTIVES This study was designed to establish the direct vascular effects of apelin in vivo in man. BACKGROUND Apelin is the endogenous ligand for the previously orphaned G-protein-coupled receptor, APJ. This novel pathway is widely expressed in the cardiovascular system and is emerging as an important mediator of cardiovascular homeostasis. In pre-clinical models, apelin causes venous and ...

We present a follow-up observation on Geballe and Oka (2010, ApJ, 709, L70), who found high column densities of H+3 100 pc apart from the Galactic center on the lines of sight to 2MASS J17432173 2951430 (J1743) and 2MASS J17470898 2829561 (J1747). The wavelength coverages on these sightlines have been extended in order to observe two key transitions of H+3 — R(3, 3) l and R(2, 2) — which constr...

BACKGROUND Apelin, the endogenous ligand for the novel G protein-coupled receptor APJ, has major cardiovascular effects in preclinical models. The study objectives were to establish the effects of acute apelin administration on peripheral, cardiac, and systemic hemodynamic variables in healthy volunteers and patients with heart failure. METHODS AND RESULTS Eighteen patients with New York Hear...

We present a follow-up observation on Geballe and Oka (2010, ApJ, 709, L70), who found high column densities of H+3 100 pc apart from the Galactic center on the lines of sight to 2MASS J17432173 2951430 (J1743) and 2MASS J17470898 2829561 (J1747). The wavelength coverages on these sightlines have been extended in order to observe two key transitions of H+3 — R(3, 3) l and R(2, 2) — which constr...

Growing evidence supports the role of gut microbiota in the development of obesity, type 2 diabetes, and low-grade inflammation. The endocrine activity of adipose tissue has been found to contribute to the regulation of glucose homeostasis and low-grade inflammation. Among the key hormones produced by this tissue, apelin has been shown to regulate glucose homeostasis. Recently, it has been prop...

Chemokines have received increasing attention due to their inhibitory activities on human immunodeficiency virus type-1 (HIV-1) and simian immunodeficiency virus (SIV) replication and the potential for chemokine receptors to assist in HIV-1/SIV entry into permissive cells. Besides CD4, which is the major receptor for HIV-1 and SIV, a number of chemokine receptors including but not limited to AP...

r-Process nucleosynthesis in material ejected during neutron star mergers may lead to radioactively powered transients called kilonovae. The timescale and peak luminosity of these transients depend on the composition of the material after nuclear burning ceases, which determines the local heating rate from nuclear decays and the opacity. Kasen et al. (2013, ApJ, 774, 25) and Tanaka & Hotokezaka...

ABSTRACT We present a large catalogue of molecular clouds with accurate distance estimates in the Southern sky. Based on three-dimensional dust extinction map and best-fitting information over 17 million stars presented Guo et al. (2021, ApJ, 906, 47), we have identified 250 dust/molecular sky using hierarchical structure identification algorithm. Amongst these are 71 located at high Galactic l...

Proper motions measured by Hipparcos confirm the large anomalous velocities of the OB associations located around the Cygnus Superbubble (Cygnus OB1, OB3, OB7, and OB9), and reveal a clearly organized expanding pattern in Canis MajorOB1.At the distances of these associations, the organized velocity patterns imply LSR velocities of up to ∼ 60 km s−1 for the associations in Cygnus, and about ∼ 15...

Apelin is a peptide originally isolated from bovine stomach tissue extracts and identified as an endogenous ligand of the APJ receptor; recent work showed that apelin ameliorates the ischemic injury in the heart and the brain. Being an analogue to the angiotensin II receptor, the apelin/APJ signaling may mediate angiogenesis process. We explored the noninvasive intranasal brain delivery method ...