Although some previous studies have suggested that triglyceride, a major core lipid, plays a key role in the assembly and secretion of apolipoprotein B-containing lipoproteins from HepG2 cells, other reports have indicated the importance of cholesteryl ester, another core lipid. We attempted to better define the roles of triglyceride and cholesteryl ester in the assembly and secretion of apolip...

introduction: hyperlipidemia is a risk factor for atherosclerosis and cardiovascular diseases. nuts such as almonds are high in unsaturated lipids and antioxidants. some studies indicate that nuts have beneficial effects on cardiovascular system. therefore, the aim of this study was evaluation of the effectiveness of shelled almonds on reduction of blood lipid and lipoprotein levels in hyperlip...

background: we aimed here to investigate the association between alleles and genotypes of apoe and age-related macular degeneration (amd) development. materials and methods: after ophthalmological examination, 120 patients with confirmed amd and 120 healthy controls were enrolled in the study. the polymorphic segment of apoe gene was pcr-amplified and sequenced to determine the frequency distri...

High density lipoproteins of rat blood plasma were labeled in vitro with radioiodinated apolipoprotein E and biologically with [3H]cholesteryl esters. These two components, present in high density lipoproteins separated from serum of normal or cholesterol-fed rats by molecular sieve chromatography, were removed slowly from perfused livers and the labeled apolipoprotein E was also removed slowly...

BDNF has potent effects on neural synapses and its pathway affects cell survival other biological processes. Kaempferia galanga L. many active substances with antioxidant anti-inflammatory effects. We analyzes in four different group of Wistar rats (Ratus novergicus) into Groups A (no trauma & extract), B (with no C 600 mg/kgbw D 1200 extract). B, C, are further divided those who had their ...

We describe here two patients, M. P. and S. L., with recessive abetalipoproteinemia. Analysis of restriction fragments of DNA from both patients using cDNA probes spanning the entire apolipoprotein B gene revealed no major insertions or deletions. Further, as defined by restriction fragment length polymorphism, abetalipoproteinemia, in these patients, did not appear associated with particular a...

b a ckground: the objective was to investigate the relationship between serum interleukin-18 (il-18), pentraxin 3 (ptx3), and high-sensitivity c-reactive protein (hs-crp) levels with body mass index (bmi) and abdominal obesity and also the interaction between genetic variants of apolipoprotein a-ii (apo a-ii) and obesity on the levels of these factors in type 2 diabetes patients (t2d). m ethods...

multiple sclerosis (ms) is a chronic inflammatory disorder of the central nervous system, with a complex etiology that includes a strong genetic component. the chromosome 19q 13 region surrounding the apolipoprotein e (apoe) gene has shown consistent evidence of involvement in ms. in a cross-sectional study, to show the apoe genotype and allele frequency in the ms population of iran in comparis...

We determined the common polymorphism of apolipoprotein E (E2, E3, and E4), apolipoprotein B Xba I polymorphism, and apolipoprotein C-III Sst I polymorphism in almost all Finnish centenarians alive in 1991 (n = 179/185). Plasma lipid and lipoprotein levels in different apolipoprotein genotypes were also measured. In comparison with younger Finnish populations studied previously, the frequency o...

The expression of apolipoprotein E in cultured neonatal rabbit aortic smooth muscle cells was examined. Northern blot analysis determined that there was a single RNA transcript of approximately 1.2 kb. Moreover, a polyclonal antibody against rabbit apolipoprotein E was prepared in a goat and used in immunoprecipitations to demonstrate that the cultured cells secreted apolipoprotein E into the m...