Purpose: To investigate the influence of elemene on growth and apoptotic changes in bladder cancer cells, involvement phosphatase tensin homologous protein (PTEN)-serine/threonine kinase (Akt) signal pathway process.
 Methods: Human cell line SV-HUC-1 human T24 were randomly assigned to blank control group groups. Protein expression levels apoptosis-related factors (Bcl-2, Bax, caspase-3] ...

Background/Aim. Amalgam has been used for years in dentistry, but the controversy on its adverse effects, both local oral/dental tissues and systemic health, still exists. When retrograde filling apical surgery, amalgam comes close contact with periapical tissue, it is sometimes responsible induction of lesion (PL) or exacerbation. Therefore, aim study was to examine effect cytotoxicity product...

Abstract: Aim/Background: Cancer is still known to be a devastating disease condition. Even after getting advancements in multimodality therapies, the success rate with respect patient survival very limited. Hence there an emerging need find alternative medication strategies for cancer treatment. Recently seaweeds are their significance due its tremendous medicinal properties. Among different c...

Background: Liver cancer is associated with a high mortality rate worldwide. Hepatocellular carcinoma (HCC) constitutes large proportion of primary liver cancers, and most its alterations currently remain untreatable. Diallyl trisulfide (DATS), the main chemical constituent allicin, affects tumour development by regulating cell apoptosis. Allicin-induced autophagy could contribute to apoptosis ...

Purpose: Alzheimer’s disease (AD) is a common in the world caused by deposition brain parenchyma, accumulation of beta amyloid which leads to blood barrier (BBB) disruption. Regardless enough progress treatment AD, principal mechanism BBB injury yet not clear.Methods: In this study we examined impact EGb761on Aβ 1-42-induced SH-SY5Y cells vitro model AD. Cell viability was assessed using MTT as...

Dry eye disease (DED) is a common chronic ophthalmic disorder, and there no effective treatment to cure it. It urgent find new antidry compounds. Here, the effects underlying mechanisms of tilapia skin peptides (TSP) on DED were investigated. In vitro, human corneal epithelial cells (HCECs) cultured in hypertonic medium containing TSP for 12 h. The MTT assay, calcein-AM/PI staining, reactive ox...

Plants continue to play a critical role in the discovery of effective compounds, especially anticancer drugs. Abutilon pannosum has been historically used as therapeutic plant medicinal system. In this study, an ethanolic crude extract was prepared from dried powder A. and subsequently fractionated produce chloroform, butanol, water fractions. The fractions were tested for their cytotoxic actio...

objective(s) cigarette and nicotine enhances embryogenesis, fertility, pregnancy loss and ultrastructure alterations of oocyte. this study was performed to determine the effect of daily supplementation of vitamin e on oocytes apoptosis in nicotine-treated mice. materials and methods in this experimental study, 24 nmari adult female mice were randomly allocated into four experimental groups. for...

The natural product Ginkgolide B was used as a raw material and modified by esterification on C10-OH or C1-OH to obtain 11 derivatives (1–11), which were structurally characterized with nuclear magnetic resonance spectroscopy. An MTT assay-based in vitro tumor proliferation inhibitory activity test showed that compounds 2, 3, 6, 7, 10, exhibited strong against the human ovarian cancer cells SKO...

Background: Cancer refers to the abnormal growth of cells and is still the most common cause of morbidity in world. The purpose of this study was to determine cytotoxicity effect of high molecular weight (HMWC) and low molecular weight of chitosan (LMWC) on three cancerous cell lines MCF-7, HeLa and Saos-2 with different histological origin. Methods: The anticancer property of two types of chi...