Hot-melt extrusion is one of the most widely applied processing technologies in the plastic, rubber and food industry. Today this technology has found its place in the array of pharmaceutical manufacturing operations. Melt extrusion process are currently applied in the pharmaceutical field for the manufacture of a variety of dosage forms and formulations such as granules, pellets, tablets, supp...

Manufactured nanoparticles have a wide range of application due to their advantageous properties whencompared with their bulk forms. There is a growing concern regarding the safety of nanoparticles. This studyaimed to evaluate the cell membrane lipoperoxidation (LPO) and DNA integrity in red earthworm Lumbricusrubellus when exposed to artificial soil systems containing different concentration o...

Thirteen kinds of over-the-counter pharmaceuticals with small side effects and fast treatment effects became available in retail stores or convenience stores as well as drugstores. This is expected to increase consumers’ options for drug purchases and partially resolve discomfort triggered because drugs were only available in drugstores. Nonetheless, applications that inform the locations of st...

calibration transfer method is evaluated by transferring multivariate models between two equivalent near-infrared (NIR) analyzers for the prediction of A an Active Pharmaceutical Ingredient (API) in tablets. The method includes selecting a few representative samples, building a transformation relation, and standardizing spectra. Backward and forward transfer approaches are compared. A practical...

Prescription drug costs can be astronomical. The advent of generic drugs, which sell at substantially lower prices than their brand-name counterparts, can save consumers billions of dollars per year. The Hatch-Waxman Act, which governs the introduction of generic pharmaceuticals into the marketplace, produces an undesired side effect-the "approval bottleneck." This Comment examines the "approva...

INTRODUCTION1, 2 In the last decade, interest in developing a combination of two or more Active Pharmaceutical Ingredients (API) in a single dosage form (bi-layer tablet) has increased in the pharmaceutical industry, promoting patient convenience and compliance. Bi-layer tablets can be a primary option to avoid chemical incompatibilities between APIS by physical separation, and to enable the de...

A search of the current scientific literature yields a limited number of studies that describe the use of Fourier transform infrared (FT-IR) spectroscopic imaging for the analysis of forensic casework, which is likely due to the fact that these instruments are fairly new commodities to the field of analytical chemistry and are therefore not yet commonplace in forensic laboratories. This report ...

     A special type of silica-based columns has been recently introduced into the market which is called narrow-bore columns. They have lower internal volume than the standard high-performance liquid chromatography (HPLC) columns and thus reduce the solvent consumption by almost 80%.    A simple, accurate and environmentally friendly reversed phase- HPLC (RP-HPLC method) which could be used in ...

Effects of different levels of compost application on the amounts and percentage distribution of organic N forms in whole soils and particle size fractions were investigated. Soil samples were collected from three plots: a) F, only chemical fertilizers; b) F + LC, chemical fertilizers plus low level of compost; (c) F + HC, chemical fertilizers plus high level of compost. Each soil sample was di...

...................................................................................................................................................................................1 Overview...................................................................................................................................................................................1 Modeling .....................