The development of the concept of mild cognitive impairment (MCI) and its practical application have been intimately tied to attempts to produce therapeutic agents. Understanding the regulatory environment and determining the way in which it can be influenced are critical to the development of drugs and their eventual approval. In this article, we review some of the current challenges surroundi...

There is an old Chinese thought meaning that medicine and food are isogenic. In Japan, a national research project started to endorse the thought scientifically, with the birth of functional foods that are now known to function to reduce the risk of life-style related diseases. The science gave rise to a national policy in which some functional foods were legally approved in terms of Foods for ...

This comment reflects on the recent row over Woodrow Wilson's legacy, which has focussed on his undeniable racism. This was in pursuit of a 'Progressive' agenda which paved the way for the United States to become the geopolitical force that it continues to be today. Without necessarily approving of Wilson's particular judgements, I argue that he operated with a 'world-historic' sense of moralit...

Despite Medicare approving the use of positron emission tomography/computed tomography (PET/CT) in staging primary breast cancer, little evidence is available to support the use of (18)F-FDG-PET/CT for the detection of distant metastases in the initial staging of breast cancer. In this review of the literature listed in MEDLINE, we examine whether (18)F-FDG-PET/CT may play a role in the initial...

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Populations of the common bed bug, Cimex lectularius, have recently undergone explosive growth. Bed bugs share many important traits with triatomine insects, but it remains unclear whether these similarities include the ability to transmit Trypanosoma cruzi, the etiologic agent of Chagas disease. Here, we show efficient and bidirectional transmission of T. cruzi between hosts and bed bugs in a ...

This article explores motivation in a social context: how people pursue goals with others, with information on others, and for the self and others. As people incorporate close others into their extended selves (Aron et al., 1991), they begin to treat others’ actions and outcomes as partially their own. This tendency, in turn, has implications for coordinating goal pursuits with others and for t...

US senators agreed late on 26 March to “set aside” a proposal to create a special approval pathway at the Food and Drug Administration (FDA) for antibiotics. Public interest advocacy and government watchdog organizations celebrated the news after scrambling to urge senators to vote against the amendment, which had been added to the US congressional budget bill and introduced earlier in the day....