نتایج جستجو برای: aptasensor

تعداد نتایج: 444  

2013
Yun Kyung Jung Taemin Lee Eeseul Shin Byeong-Su Kim

A highly tunable layer-by-layer (LbL)-assembled graphene oxide (GO) array has been devised for high-throughput multiplex protein sensing. In this array, the fluorescence of different target-bound aptamers labeled with dye is efficiently quenched by GO through fluorescence resonance energy transfer (FRET), and simultaneous multiplex target detection is performed by recovering the quenched fluore...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2017
Tracy T Chuong Alessia Pallaoro Chelsea A Chaves Zhe Li Joun Lee Michael Eisenstein Galen D Stucky Martin Moskovits H Tom Soh

We present a sensitive and quantitative protein detection assay that can efficiently distinguish between specific and nonspecific target binding. Our technique combines dual affinity reagents with surface-enhanced Raman spectroscopy (SERS) and chemometric analysis. We link one Raman reporter-tagged affinity reagent to gold nanoparticles and another to a gold film, such that protein-binding even...

Journal: :Nanoscale 2015
Sajal Shrivastava Il-Yung Sohn Young-Min Son Won-Il Lee Nae-Eung Lee

Although real-time label-free fluorescent aptasensors based on nanomaterials are increasingly recognized as a useful strategy for the detection of target biomolecules with high fidelity, the lack of an imaging-based quantitative measurement platform limits their implementation with biological samples. Here we introduce an ensemble strategy for a real-time label-free fluorescent graphene (Gr) ap...

2012
Subash C. B. Gopinath Koichi Awazu Makoto Fujimaki

Aptamers are artificial nucleic acid ligands that can be generated by in vitro selection through partition and amplification. Aptamers can be generated against a wide range of biomolecules through the formation of versatile stem-loop structures. Because aptamers are potential substitutes for antibodies and drugs, the development of an aptamer-based sensor (aptasensor) is mandatory for diagnosis...

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