The release rate of a drug molecule from a porous support depends on a large number of factors, including support characteristics, surface functionalization (procedure and linker type), drug features, biological receptor fluid characteristics, and release conditions. Model-based (in-silico) modulation of the release rate through influential parameters can help in designing an optimized delivery...

Experimental section Materials Cetyltr imethyl ammonium bromide (C16TAB), tetraethyl orthosilicate (TEOS), Fe3O4 NPs (ca. 20 nm) and 3,3',5,5'-tetramethylbenzidine (TMB) were obtained from Aladdin. Titanium potassium oxalate (K2TiO(C2O4)2·2H2O), hydrogen peroxide (H2O2, 30%) and potassium ferricyanide were purchased from Sinopharm Chemical Reagent Co., Ltd. Potassium ferrate (K2FeO4), 3-aminopr...

In this paper the results concerning the synthesis of magnetite (Fe₃O₄) nanoparticles (NPs), their functionalization using silane derivatives, such as (3-Aminopropyl)triethoxysilane (APTES) and (3-mercaptopropyl)trimethoxysilane (MPTMS), and their exhaustive morphological and physical characterization by field emission scanning electron microscopy (FE-SEM) with energy dispersion X-ray spectrome...

A rapid and simple procedure was developed for the preparation of a highly stable and leach-proof glucose oxidase (GOx)-bound glassy carbon electrode (GCE). Crosslinked GOx via glutaraldehyde was drop-cast on a KOH-pretreated GCE followed by drop-casting of 3-aminopropyltriethoxysilane (APTES) to form a stable bioactive layer. At -0.45 V, the biosensor exhibited a wide dynamic detection range o...

Department of Organic Chemistry, Faculty of Chemistry, University of Kashan, Kashan, 87317, I.R. Iran. Nanobiotechnology Research Center, Avicenna Research Institute, ACECR, 1936773493, Tehran, Iran. [email protected]. Abstract: In this study we have developed a simple, cheap, and rapid method for purification of 6×histidine-tagged recombinant proteins with high yields. The new immobil...

Cellulase was immobilized onto silica gel surfaces pretreated with (3-aminopropyl) triethoxy-silane (3-APTES), and glutaraldehyde (GA) was used as a cross-linker. A carboxymethyl cellulose sodium salt (CMC) solution was used for activity experiments. Protein assay was performed to determine the mass immobilized and compare with free enzyme. Cellulase was successfully demonstrated to be immobili...

Anti-HER-3 antibody was used for the first time in a disposable immunosensor based on indium tin oxide (ITO) substrate for HER-3 quantification. Anti-HER-3 was immobilized onto ITO substrate by 3-aminopropyl)triethoxysilane (APTES) and glutaraldehyde. This highly sensitive immunosensor was capable of detecting concentrations of HER-3 down to the femtogram/ml level by investigating changes in th...

CoFe nanowires have been synthesized by the electrodeposition technique into the pores of a polycarbonate membrane with a nominal pore diameter of 50 nm, and the composition of CoFe nanowires varying by changing the source concentration of iron. The synthesized nanowire surfaces were functionalized with amine groups by treatment with aminopropyltriethoxysilane (APTES) linker, and then conjugate...

Various nanocomposite materials play a number of important roles in modern science and technology including pharmaceutical science. Among these materials, mesoporous materials cover a large number of applications in drug delivery system. The quantitative incorporation and high dispersion of selenium nanoparticles into MCM-41 have been made possible by the coordination between Se(IV) ion and ami...