Enzyme-prodrug approaches to cancer therapy, theoretically, have the potential to mediate tumor-selective cytotoxicity. However, even if tumor-specific prodrug activation is achieved, enzyme-prodrug systems investigated thus far comprised a single enzyme and a specific prodrug. Although targeted, such systems constitute single-agent therapy, which may be ineffective and/or may promote developme...

the principle of equality of arms means that each party in an action shall present her claim in an environment so that this does not put him in a worse condition compared to the other party of the trial. this principle has been internationally and locally embraced by authorities. from the perspective of international documents, the acceptance of this principle is partly influenced by the accept...

Dynamic programming is a classical programming technique, applicable in a wide variety of domains such as stochastic systems analysis, operations research, combinatorics of discrete structures, flow problems, parsing of ambiguous languages, and biosequence analysis. Little methodology has hitherto been available to guide the design of such algorithms. The matrix recurrences that typically descr...

The directed percolation (DP) hypothesis for stochastic, range-4 cellular automata with acceptance rule y ≤ ∑ 4 j=−4 si−j ≤ 6, in cases of y < 6 was investigated in one and two dimensions. Simulations, mean-field renormalization group and coherent anomaly calculations show that in one dimension the phase transitions for y < 4 are continuous and belong to the DP class for y = 4, 5 they are disco...

Recently, the dependency pairs (DP) approach has been generalized to context-sensitive rewriting (CSR). Although the context-sensitive dependency pairs (CS-DP) approach provides a very good basis for proving termination of CSR, the current developments basically correspond to a ten-years-old DP approach. Thus, the task of adapting all recently introduced dependency pairs techniques to get a mor...

Abstract. In this paper, a FETI-DP formulation for three dimensional elasticity on non-matching grids over geometrically non-conforming subdomain partitions is considered. To resolve the nonconformity of the finite elements, a mortar matching condition is imposed on the subdomain interfaces (faces). A FETI-DP algorithm is then built by enforcing the mortar matching condition in dual and primal ...

In this study, we considered a fractional parabolic equation for identifying the unknown diffusion coefficient from noisy measurement of ultimate time solution. It is an inverse problem involving nonlocal operator that nonlinear and poorly formulated. By demonstrating existence singular solution with regard to final observed data, demonstrate identifiability problem. The expressed as regularize...