BACKGROUND Allergy immunotherapy (AIT) is the only treatment for allergic rhinitis (AR) and/or allergic asthma (AA) with long-term efficacy. However, there are few real-life data on the progression of AR and/or AA in patients receiving AIT. OBJECTIVES To assess the real-world, long-term efficacy of grass pollen sublingual immunotherapy (SLIT) tablets in AR and their impact on asthma onset and...

Doppler indexes have been used successfully to determine the severity of aortic regurgitation (AR) in adults but have not been evaluated in children. To determine the accuracy of pulsed, color, and continuous-wave (CW) Doppler echocardiographic indexes in assessing the degree of AR in children, the correlation between the non-invasive measurements and angiographic grading of the regurgitant flo...

Rohdin, Malin, Patrik Sundblad, and Dag Linnarsson. Effects of hypergravity on the distributions of lung ventilation and perfusion in sitting humans assessed with a simple two-step maneuver. J Appl Physiol 96: 1470–1477, 2004. First published December 12, 2003; 10.1152/japplphysiol.00627.2003.—Increased gravity impairs pulmonary distributions of ventilation and perfusion. We sought to develop a...

BACKGROUND New onset diabetes mellitus (NODM) and acute rejection (AR) are important causes of morbidity and risk factors for allograft failure after kidney transplantation. METHODS In this multi-center, open label, single-arm pilot study, 49 adult (≥18 years of age), low immunologic risk, non-diabetic recipients of a first deceased or living donor kidney transplant received early steroid red...

BACKGROUND It has been suggested that there is some overlap between allergic rhinitis (AR), sinusitis and polyposis, but this has not been fully documented. The present study aimed to evaluate the prevalence of these co-existing diseases and their impact on bronchial asthma in the general population of Italy. METHODS Within the frame of the multicentre Gene Environment Interactions in Respira...

In this study, the authors sought to determine whether single nucleotide polymorphisms in the estrogen receptor alpha (ESR1) and matrix metalloproteinase 2 (MMP2) genes are associated with age-related maculopathy (ARM) in older women. Subjects comprised a random sample of Caucasian women aged > or =74 years participating in the Study of Osteoporotic Fractures year 10 follow-up (n = 906) in 1997...

The unfolded protein response (UPR) is a homeostatic mechanism to maintain endoplasmic reticulum (ER) function. The UPR is activated by various physiological conditions as well as in disease states, such as cancer. As androgens regulate secretion and development of the normal prostate and drive prostate cancer (PCa) growth, they may affect UPR pathways. Here, we show that the canonical UPR path...

Many contr olapplications ar e by nature distributed, not only over di erent processesbut also over several pr ocessors. Managing such a system with resp ectto the startup of pr ocesses,internal communications and state changes quickly becomesa very complex task. This pap erpr esents a distributed contr olar chite ctur e which supports a formal model of computation as described by [1]. The ar c...

A detector for the case of a radar target with known Doppler and unknown complex amplitude in complex Gaussian noise with unknown parameters has been derived. The detector assumes that the noise is an Auto-Regressive (AR) process with Gaussian autocorrelation function which is a suitable model for ground clutter in most scenarios involving airborne radars. The detector estimates the unknown...

Objective: To evaluate the efficacy of anthropometric and body composition parameters in the prediction of body fat percentage and lipid profile in schoolchildren. Methods: Cross-sectional study with 209 schoolchildren aged between seven and nine years old. The following variables were evaluated: weight, height, body mass index, percentage of body fat, arm and waist circumferences, conicity ind...