Total syntheses of alkaloid cis-223B and xenovenine are reported in 3 and 4 steps respectively using a two-directional synthesis/triple reductive amination strategy, and their neurotoxic properties assessed.

Amines are the most important building blocks employed in modern medicinal chemistry. Secondary amines are regularly prepared by the alkylation or reductive amination of the parent amines through transition metal, typically precious metals, catalyzed reactions. In the past few years, the catalytic alkylation of amines with alcohols under hydrogenborrowing conditions as well as the catalytic red...

Highly purified preparations of glutamate synthase catalyze the TPNH-dependent reductive amination of cu-ketoglutarate to form L-glutamate in the presence of either L-glutamine or NH:,. Preparations of the enzyme that lack flavins (FAD and FMN) or the flavins and iron sulfide, catalyzed NH,,-mediated glutamate synthesis, but not glutamine-mediated glutamate synthesis. Participation of enzyme-fl...

The transamination of alkyl-palladium halide N-heterocyclic carbene complexes has enabled the isolation of products that reveal interesting insights into the factors which might be barriers to the development of a palladium-catalysed alkyl-amination reaction.

Dialkylbiaryl phosphines are a valuable class of ligand for Pd-catalyzed amination reactions and have been applied in a range of contexts. This review attempts to aid the reader in the selection of the best choice of reaction conditions and ligand of this class for the most commonly encountered and practically important substrate combinations.

THE TITLE COMPOUND (SYSTEMATIC NAME 12-{[2-(4-hydroxyphenyl)ethyl]aminomethyl}-4,8-dimethyl-3,14-dioxatricyclo[9.3.0.0(2,4)]tetradec-7-en-13-one monohydrate), C(23)H(31)NO(4)·H(2)O, was obtained by the reaction of tyramine with parthenolide. The configuration of the new chiral center in the title compound is R, establishing the stereospecificity of the amination reaction. The water molecule is ...

Pd(II)-catalyzed intramolecular amination of arenes is developed using either a one- or two-electron oxidant. The reaction protocol tolerates a wide range of deactivating groups including acetyl, cyano, and nitro groups. This catalytic reaction allows expedient syntheses of broadly useful substituted indolines or indoles.

Thiol-ene coupling interestingly allowed to synthesize reactive primary and multi-functional amines from renewable resources with high yield and in mild conditions. These syntheses were performed in two steps from triallyl pentaerythritol (PE-Al) by esterification of the hydroxyl function with a long or medium alkyl chain and thiol-ene coupling with the cysteamine hydrochloride on the allyl fun...

Z. Naturforsch. 56 b, 901-907 (2001); received June 5, 2001 Macrocyclic Ligands, Nitrogen, Sulfur The ability of the aromatic tetraaldehyde l,2-bis(4-rm-butyl-2,6-diformylphenylsulfanyl)ethane (1 ) to function as a precursor in the preparation of binucleating hexaamine-dithiolate lig­ ands has been investigated. Reductive amination of compound 1 with bis(aminoethyl)amine un­ der medium-dilution...

A matrix A can be tested to determine whether it is eventually positive by ex1 amination of its Perron-Frobenius structure, i.e., by computing its eigenvalues and left and right 2 eigenvectors for the spectral radius ρ(A). No such “if and only if” test using Perron-Frobenius prop3 erties exists for eventually nonnegative matrices. The concept of a strongly eventually nonnegative 4 matrix was wa...