CONTEXT Obesity is associated with atrial enlargement and ventricular diastolic dysfunction, both known predictors of atrial fibrillation (AF). However, it is unclear whether obesity is a risk factor for AF. OBJECTIVE To examine the association between body mass index (BMI) and the risk of developing AF. DESIGN, SETTING, AND PARTICIPANTS Prospective, community-based observational cohort in ...

OBJECTIVES We studied the effects of beta-adrenergic and cholinergic stimulation and blockade on spontaneous atrial fibrillation (AF) in the intact dog heart. BACKGROUND Paroxysmal AF is often preceded by changes in autonomic tone, but the relative roles of adrenergic and cholinergic influences on AF induction are not well known. METHODS Perfusion of catecholamines and acetylcholine (ACh), ...

BACKGROUND Atrial fibrillation (AF) and heart failure (HF) are 2 of the most common cardiovascular conditions nationally and AF frequently complicates HF. We examined how AF has impacts on adverse outcomes in HF-PEF versus HF-REF within a large, contemporary cohort. METHODS AND RESULTS We identified all adults diagnosed with HF-PEF or HF-REF based on hospital discharge and ambulatory visit di...

BACKGROUND Atrial fibrillation(AF) is the most common arrhythmia in the adult population. The activated renin-angiotensin-aldosterone system (RAS) has been reported to play an important role in the pathogenesis of atrial fibrillation. The aim of this study was to investigate the association between nonfamilial AF and polymorphisms in RAS gene. METHODS A total of 931 patients with nonfamilial ...

Program Number: 6371 Poster Board Number: C0148 Presentation Time: 12:00 PM–1:45 PM Spectrum of Retinal Pigment Epithelium Abnormalities in Central Serous Chorioretinopathy as Revealed by UltraWidefield Autofluorescence Juliana E. Boneta2, 1, Lawrence A. Yannuzzi4, Sanjeev Nath3, Sherry J. Bass1, Jerome Sherman1, 3. 1SUNY College of Optometry, New York, NY; 2Fromer Eye Centers, New York, NY; 3E...

BACKGROUND Atrial fibrillation (AF), whether silent or symptomatic, is a frequent and severe complication of acute myocardial infarction (AMI). Asymmetric dimethylarginine (ADMA), an endogenous eNOS inhibitor, is a risk factor for endothelial dysfunction. We addressed the relationship between ADMA plasma levels and AF occurrence in AMI. METHODS 273 patients hospitalized for AMI were included....

Hypertension is the most prevalent risk factor for incident atrial fibrillation (AF). Recently, even high normal blood pressures (BPs) have been established as predictive of AF in women. We aimed to study the long-term impact of upper normal BP on incident AF in a population-based study of middle-aged men. From 1972 to 1975, 2014 healthy Norwegian men were included in a prospective cardiovascul...

BACKGROUND Obesity is an important risk factor for nonalcoholic fatty liver disease and atrial fibrillation (AF). Less is known about the relations between nonalcoholic fatty liver disease and AF. We sought to evaluate the association between fatty liver and prevalent and incident AF in the community. METHODS AND RESULTS We examined Framingham Heart Study participants who underwent a study-di...

Atrial fibrillation (AF) is the most common sustained arrhythmia, causing a 2-fold increase in mortality and a 5-fold increase in stroke. The Asian population is rapidly aging, and in 2050, the estimated population with AF will reach 72 million, of whom 2.9 million may suffer from AF-associated stroke. Therefore, stroke prevention in AF is an urgent issue in Asia. Many innovative advances in th...

Background: Approximately 25% of strokes are cryptogenic in origin and identifying atrial fibrillation (AF) as an etiologic factor in this situation has major therapeutic implication. Standard Holter ECG has a low sensitivity for AF detection in this patient group. Aim: To assess the diagnostic yield of prolonged ambulatory noninvasive ECG telemonitoring for AF detection in cryptogenic stroke o...