INTRODUCTION The proteins found in tears play an important role in maintaining the ocular surface and changes in tear protein components may reflect changes in the health of the ocular surface. Proteomics provides a comprehensive approach for cataloguing all the proteins of the tear proteome, which will help to elucidate disease pathogenesis, make clinical diagnoses and evaluate the influence o...

INTRODUCTION: Subscapularis (SSC) tendon tear is detected in about 20-40% of the patients with rotator cuff tear during surgery. Magnetic resonance imaging (MRI) scans have been used as a diagnostic tool for predicting the presence of SSC tear. But it is difficult to diagnose the SSC tear correctly. The purpose of this study is to evaluate the significance of various preoperative MRI findings t...

BACKGROUND The exact anatomical cause of the tear trough remains undefined. This study was performed to identify the anatomical basis for the tear trough deformity. METHODS Forty-eight cadaveric hemifaces were dissected. With the skin over the midcheek intact, the tear trough area was approached through the preseptal space above and prezygomatic space below. The origins of the palpebral and o...

PURPOSE To determine whether intolerance to contact lens wear is attributable to clinical or protein characteristics of the tear film. METHODS Thirty-eight subjects participated; 20 were successful contact lens wearers and 18 had discontinued contact lens wear because of discomfort. Baseline tear film (no lens wear) was analyzed with a range of clinical measurements and protein analyses (lact...

PURPOSE ω-3 and ω-6 polyunsaturated fatty acids modulate inflammatory processes throughout the body through distinct classes of lipid mediators that possess both proinflammatory and proresolving properties. The purpose of this cross-sectional study was to explore the relationship between lipid profiles in human tears and dry eye (DE) symptoms and signs. METHODS Forty-one patients with normal ...

PURPOSE To assess the effect of patient education on videotaped topical instillation of artificial tear drops on subsequent topical instillation. MATERIALS AND METHODS Forty-five patients, who had been using glaucoma drops for at least 6 months and with a best-corrected visual acuity of 20/100 or better, were studied. The patients were asked to instill an artificial tear drop using their accu...

PURPOSE To evaluate and compare the efficacy and safety of two investigational artificial tear formulations (CHO-1 and CHO-2) containing carmellose sodium, hyaluronic acid at different concentrations, and osmoprotectants, with a standard carmellose sodium-containing formulation (Refresh Tears [RT]) in the treatment of dry eye disease. SUBJECTS AND METHODS In this 3-month, double-masked, multi...