INTERRUPTION of ventricular fibrillation with the use of drugs has generally been found to be unsuccessful. Previous work on local anesthetic agents suggested that such compounds could terminate ventricular fibrillation; however, Stearns, Maison and Stutzman reported little success with the use of procaine. Wegria and co-workers' conclude in their studies that procaine may stop fibrillation; ho...

OBJECTIVE To assess long term mortality and identify factors associated with the development of permanent atrial fibrillation after atrioventricular (AV) node ablation for drug refractory paroxysmal atrial fibrillation. DESIGN Retrospective cohort study. SETTING UK tertiary centre teaching hospital. PATIENTS Patients admitted to the University Hospital Birmingham between January 1995 and ...

Rhythmic fibrillation potentials are the hallmark of denervated muscle fibres in needle EMG of a striated muscle (Conrad et al. 1972, Heckmann & Ludin 1982). They are readily activated by the insertion of an EMG needle electrode (Kugelberg & Petersén 1949). Irregular fibrillation potentials may also be present (Buchthal & Rosenfalck 1966, Purves & Sakmann 1974). There is, however, an obvious di...

INTRODUCTION The purpose of our study was to evaluate the effect of repeated cardioversion with an implantable atrial defibrillator on the clinical outcome of patients with atrial fibrillation. METHODS AND RESULTS The effects of the implantable atrial defibrillator on the total duration of atrial fibrillation, number of atrial fibrillation recurrences, and left atrial size were evaluated pros...

Atrial fibrillation significantly contributes to mortality and morbidity through increased risk of stroke, heart failure and myocardial infarction. Investigations of mechanisms responsible for the development and maintenance of atrial fibrillation have highlighted the importance of gap junctional remodeling. Connexins 40 and 43, the major atrial gap junctional proteins, undergo considerable alt...

Management of atrial fibrillation in the elderly presents unique challenges, including deciding upon the best treatment strategy: rate control versus rhythm control. The decision to pursue one treatment strategy over another is based on understanding the underlying disorder: symptomatology from atrial fibrillation itself versus symptoms due to a rapid ventricular response from atrial fibrillati...

The Wolff-Parkinson-White syndrome can rarely present with pre-excited atrial fibrillation. In this condition the short refractory period of the accessory pathway can lead to rapid atrioventricular conduction. There is then a danger that at high heart rates the irregular broad complex tachycardia that results can deteriorate into ventricular fibrillation. The initial management of patients pres...

BACKGROUND Recently, interest has arisen in using biphasic waveforms for external defibrillation. Little work has been done, however, in measuring transthoracic defibrillation efficacy after long periods of ventricular fibrillation. In protocol 1, we compared the efficacy of a quasi-sinusoidal biphasic waveform (QSBW), a truncated exponential biphasic waveform (TEBW), and a critically damped si...

BACKGROUND New-onset atrial fibrillation in patients hospitalized for an acute myocardial infarction often leads to hemodynamic deterioration and has serious adverse prognostic implications; mortality is particularly high in patients with congestive heart failure and/or a reduced left ventricular ejection fraction. The mechanism of atrial fibrillation in the context of an acute myocardial infar...

atrial fibrillation during vagal nerve stimulation in the canine heart: restudying the Moe hypothesis. J Cardiovasc Electrophysiol 2013;24:328–35. 14. Haissaguerre M, Jais P, Shah DC, Takahashi A, Hocini M, Quiniou G et al. Spontaneous initiation of atrial fibrillation by ectopic beats originating in the pulmonary veins. N Engl J Med 1998;339:659–66. 15. Sahadevan J, Ryu K, Peltz L, Khrestian C...