Palladium dimers with sterically hindered phosphines have been shown to be excellent pre-catalysts for the aminocarbonylation of aryl halides to yield amides and one of them has been successfully employed as a pre-catalyst for the synthesis of (11)C-radiolabelled amides for PET imaging.

A variety of 2-hydroxy aldehydes on reaction with 3-butenoic acid afford in a one-pot reaction the corresponding 3-vinylcoumarins. As expected, extension of the delocalized π-electron system accomplished by Heck coupling reactions with aryl halides results in an increased fluorescence of the compounds whose applicability is yet to be established.

A copper-mediated methylthiolation of aryl halides with the widely available DMSO is described. The procedure tolerates a series of functional groups such as methoxy, nitro, chloro, fluoro, trifluoromethyl, formyl and methoxycarbonyl groups. Thus, it represents a simple and facile methylthiolation procedure.

The phthalimide anion reacts by the SRN1 mechanism under photostimulation with different substrates. Whilst with 1-iodonaphthalene only reduction of the naphthyl radical is observed, with 1-iodoadamantane coupling at the carbon instead of at the nitrogen takes place. Introduction The mechanism of Radical Nucleophilic Substitution (SRN1) is a chain process with radicals and radical anions as int...

It was previously reported that the palladium-catalyzed cross-coupling reaction of 1-alkenylboron compounds with various vinylic or aryl halides in the presence of base provides the corresponding coupling products in high yields, stereoand regioselectively. The recent progress of such reactions, including the reaction of sterically hindered arylboronic acids with sterically hindered haloarenes,...

The chemical procedure was formerly achieved by the preliminary formation of aryl-lithium reagents followed by transmetallation with zinc halides. Nevertheless, this method is not easily achieved with aryl compounds bearing reactive functional groups such as ketone, nitrile or ester, since very low reaction temperatures are required. Alternatively, the Rieke method, which uses activated zinc ob...

An efficient Pd catalyst for the O-arylation of ethyl acetohydroximate with aryl chlorides, bromides, and iodides has been developed. Ethyl acetohydroximate serves as an efficient hydroxylamine equivalent for C-O cross-coupling, thereby allowing for the preparation of O-arylhydroxylamines from simple aryl halides. Short reaction times and broad substrate scope, including heteroaryl coupling par...

A facile and less expensive monophosphinite ligand 2-(diphenylphosphinoxy)-naphthyl, C H OPPh (1) has been synthesized from the reaction 10 7 2 f -naphthol with chlorodiphenylphosphine. The mixture of Pd(OAc)2 and 1 catalyzes the Suzuki cross-coupling of a variety of aryl halides with ryl boronic acids at room temperature or at 60 ◦C, giving generally high yields even under low catalytic loads....

An efficient palladium-catalyzed process has been developed for Negishi coupling of secondary alkylzinc halides with a wide range of aryl bromides and activated aryl chlorides. A palladium catalyst composed of a new biaryldialkylphosphine ligand, CPhos, effectively promotes the rate of the reductive elimination step relative to the rate of the undesired beta-hydride elimination. The broad subst...