Some methoxy-, hydroxyl-, pyridyl-, or fluoro-substituted 3,5-bis(arylidene)-4-piperidones (BAPs) could reduce inflammation and promote hepatoma cell apoptosis by inhibiting activation of NF-?B, especially after introduction trifluoromethyl. Herein, a series trifluoromethyl-substituted BAPs (4-30) were synthesised the biological activities evaluated. We successfully found most potential 16, whi...