Plectin is a major component of the cytoskeleton and links the intermediate filament system to hemidesmosomes by binding to the integrin 4 subunit. Previously, a binding site for 4 was mapped on the actin-binding domain (ABD) of plectin and binding of 4 and F-actin to plectin was shown to be mutually exclusive. Here we show that only the ABDs of plectin and dystonin bind to 4, whereas those of ...

Article Woerner-Powell, Tom: Another Road to Damascus: An Integrative Approach ‘Abd al-Qādir al-Jazā’irī (1808–1883) was published on June 15, 2022 in the journal Asiatische Studien - Études Asiatiques (volume 0, issue 0).

Two new blind species of Sinella are described from Guangdong Province, China. Sinella colubra sp. n. possesses minute smooth postlabial chaetae, long mucronal spine, and 4+4(5) lateral mac on Abd. IV, and can be distinguished from two closely related species by the postlabial chaetae and the dorsal macrochaetotaxy. Sinella zhangi sp. n. is also described and can be diagnosed by having minute l...

We construct a novel recombinant secondary antibody mimic, GST-ABD, which can bind to the Fc regions of target-bound primary antibodies and acquire multiple HRPs simultaneously. We produce it in tenth of mg quantities with a bacterial overexpression system and simple purification procedures, significantly reducing the manufacturing cost and time without the use of animals. GST-ABD is effectivel...

In an attempt to produce a form of chronic neurogenic hypertension without the increased blood pressure lability which is characteristic of total baroreceptor removal, selective aortic baroreceptor deafferentation (ABD) was performed in rats. Blood pressure, blood pressure variability, heart rate, plasma and extracellular fluid volumes, and the effect of total autonomic blockade were determined...