Experimental evidence is presented which confirms the reports by Shope (1, 2) that swine lungworms can serve as an intermediate host in transmitting swine influenza virus to pigs. The virus is present in a masked non-infective form as he showed and a provocative stimulus is necessary to initiate infection. Multiple injections of Ascaris extract or the migration of Ascaris larvae furnished the n...

Evidence that the swine lungworm can serve as reservoir and intermediate host for the hog cholera virus has been presented. The virus, however, is ordinarily carried in a masked form and must be provoked to pathogenicity by some stress before it can cause apparent disease. In the present experiments, ascaris larvae supplied the provocation needed to induce hog cholera in swine carrying lungworm...

Ascaris suum and Ascaris lumbricoides exhibit an over-dispersed frequency distribution in their host populations in both the adult and larval stages. The impact of host factors on this observed distribution is still poorly understood and difficult to investigate in the natural host populations. The use of a mouse model has been supported by the observations that the larval migratory pattern, in...

A study was conducted to evaluate and compare the efficacy of two injectable formulations of ivermectin (IVM-1 and IVM-2) at a dose rate of 0.3 mg/kg bodyweight versus placebo in the treatment and control of larval and adult stages of Ascaris suum and Oesophagostomum spp. in experimentally infected pigs. Seventy helminth free pigs were allocated on a liveweight basis to 7 groups each comprising...

The underlying mechanism of predisposition to Ascaris infection is not yet understood but host genetics are thought to play a fundamental role. We investigated the association between the Intelectin-2 gene and resistance in F2 mice derived from mouse strains known to be susceptible and resistant to infection. Ascaris larvae were isolated from murine lungs and the number of copies of the Intelec...

As-p18 is a fatty-acid-binding protein from the parasitic nematode Ascaris suum. Although it exhibits sequence similarity to mammalian intracellular fatty-acid-binding proteins, it contains features that are unique to nematodes. Crystals were obtained, but initial diffraction data analysis revealed that they were composed of a number of `microdomains'. Interpretable data could only be collected...

An anticoagulant has been purified from the body fluid of Ascaris suum by sequential passage through Sephadex G-50, CM-cellulose and Sephadex G-25 columns then treated with 2 M NaCl, passaged through a Sephadex G-25 column, separated from the phosphate buffer by precipitation of the latter with the CaCl2, then passaged through a Sephadex G-10 column in water. In the body fluid of the worm, the ...

In an attempt to fractionate Cg acids produced by Ascaris with the aid of partition chromatography, it was noted that one fraction had distribution characteristics resembling those of n-valeric acid (2). Elution of this fraction began earlier than, but was completed simultaneously with, that of n-Valerie acid. Therefore, it appeared that this fraction may consist of at least two components. Evi...