OBJECTIVE To test whether ascorbic acid supplementation has any cytoprotective effect on a model of secondary biliary cirrhosis in young rats. METHODS We studied 40 Wistar rats weaned at the 21st postnatal day. Each group of 10 was subjected to one of the following four treatments, until 49th postnatal day, when they suffered euthanasia: 1) LC-double ligature and resection of the common bile ...

The effect of ascorbic acid and lemon juice on the silkworm, Bombyx mori has been studied with reference to larval growth, protein synthesis and silk production. Both these exogenous factors, when supplemented with mulberry diet, showed positive impact on larval growth during the fourth and fifth instar developmental stages. The analysis of growth trends in terms of compound periodical growth r...

Large changes occur in the ascorbate system during the development of Vicia faba seed and these appear closely related to what are generally considered to be the three stages of embryogenesis. During the first stage, characterized by embryonic cells with high mitotic activity, the ascorbic acid/dehydroascorbic acid ratio is about 7, whereas in the following stage, characterized by rapid cell el...

Ascorbic acid has many nonenzymatic actions and is a powerful water-soluble antioxidant. It protects low density lipoproteins from oxidation and reduces harmful oxidants in the central nervous system. Pilocarpine-induced seizures have been suggested to be mediated by increases in oxidative stress. Current studies have suggested that antioxidant compounds may afford some level of neuroprotection...

previous studies had reported that extracellular levels of ascorbic acid have modulatory effects on dopamine receptors. both ascorbic acid and dopamine receptor have an important role in learning and memory processes. however, the central interaction between ascorbic acid and dopamine d2 receptor on spatial learning and memory has not yet been elucidated. all experiments were carried out on mal...

Repeated administration of nicotine causes incentive and behavioral sensitization in animals. Ascorbic acid administration inhibits some effects of nicotine. In the present study, the effect of ascorbic acid administration on nicotine-induced behavioral sensitization in Male Swiss-Webster mice (20-25 g) was investigated. Animals were injected with nicotine (0.25 mg/kg, i.p.) once daily for seve...

ABSTRACT: The history of food science, technology and nutrition and their expansion in respect of raw material, processing, finished products and nutritional value goes back to many years and is still the interests of many researchers. In this work ascorbic acid has been taken not only as an important and vital vitamin to be investigated during the course of different heat processes but also as...

Various investigators have reported changes in the concentration of the free amino acids in blood plasma and tissues of guinea-pigs in acute vitamin C deficiency. Christensen & Lynch (1948) found in guinea-pigs deficient in ascorbic acid a large decrease in the glycine and glutamine contents of skeletal muscle and in the glutamine content of the liver. Levels of amino acids other than glycine a...

Vitamin C (ascorbic acid) is essential to prevent disease associated with connective tissue (e.g., scurvy), improves cardiovascular and immune cell functions, and is used to regenerate alpha-tocopherol (vitamin E). In contrast to most animals, humans lack the ability to synthesize ascorbic acid as a result of a mutation in the last enzyme required for ascorbate biosynthesis. Vitamin C, therefor...

course similar to that of the other tissues during the first 8-10 days, but after that time until the premortal stage a residue persists which gives the Roe & Kuether reaction and which reduces indophenol. 5. Scurvy develops in guinea-pigs when the curve of the ascorbic acid tissue concentration reaches asymptotic values for long periods of depletion, and there is no definite correlation betwee...