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Placenta accreta spectrum includes the full range of abnormal placental attachment to uterus or other structures, encompassing placenta accreta, increta, percreta, morbidly adherent placenta, and invasive placentation. The incidence has increased in recent years, largely driven by increasing rates cesarean delivery. Prenatal detection is primarily made ultrasound important reduce maternal morbi...

This year’s research focused on further evaluation of potential alternate bearing with multiple year ReTainTM treatments. After three years of treatment with ReTainTM, there does not appear to be any negative effect on yield. There was a lower reduction in PFA than was expected, but this is thought to be unrelated to multiple year treatments. Treatment of a Chandler orchard with ReTainTM was do...

We present an approximation to the quantum Coulomb plasma at equilibrium which captures the power-law violations of Debye screening which have been reported in recent papers. The objectives are: (1) to produce a simpler model which we will study in forthcoming papers, (2) to develop a strategy by which the absence of screening can be proven for the low density quantum Coulomb plasma itself. 1 T...

Psoriasis is a debilitating skin disease characterized by epidermal thickening, abnormal keratinocyte differentiation, and proinflammatory immune cell infiltrate into the affected skin. IL-17A plays critical role in etiology of psoriasis. ACT1, an intracellular adaptor protein putative ubiquitin E3 ligase, essential for signal transduction downstream receptor. Thus, signaling general, ACT1 spec...

Free AccessGeneralizability, Replicability, and New Insights Derived From Registered Reports Within Understudied PopulationsIntroduction to the Special IssuePeter A. Edelsbrunner, Kai Ruggeri, Kaja Damnjanović, Samuel Greiff, Jérémy E. Lemoine, Matthias ZieglerPeter EdelsbrunnerPeter ETH Zurich, RZ H16, Claussiusstrasse 59, 8092 [email protected] Department of Human...

A stratified medicine approach for the treatment of psoriasis promises greater certainty clinical decision making through prediction response on basis clinical, pharmacological, and -omics data from an individual patient. As yet, there is no predictive model in routine use psoriasis. The Psoriasis Stratification to Optimise Relevant Therapy (PSORT) Consortium a United Kingdom Medical Research C...

Psoriasis is a complex, chronic inflammatory skin disease characterized by keratinocyte hyperproliferation and disordered immune response; however, its exact etiology remains unknown. To better understand the regulatory network underlying psoriasis, we explored landscape of chromatin accessibility using an assay for transposase-accessible sequencing analysis 15 psoriatic, 9 nonpsoriatic, 19 nor...

•High-glucose-induced ROS promotes phosphorylation of AMPKα at S485/491 by AKT•Phosphorylation is required for recruitment E3 ligase MG53•MG53 mediates skeletal muscle ubiquitination and subsequent degradation•High glucose also deactivates inducing disassociation from LKB1 As a master regulator metabolism, AMP-activated protein kinase (AMPK) activated upon energy shortage but suppressed overnut...

World-wide, invasive species threaten the capacity of ecosystems to sustain biodiversity and deliver critical ecosystem services (Pyšek et al., 2012). To effectively prevent control their negative impacts now in future, a predictive understanding invasion success is required (González-Moreno 2014). However, predicting challenging due its contingency on myriad interdependent abiotic biotic drive...