نتایج جستجو برای: aso titers
تعداد نتایج: 15782 فیلتر نتایج به سال:
We are currently conducting clinical trials of E1A gene therapy for patients with ovarian cancer. The adenovirus type 5 E1A gene suppresses growth of ovarian cancer cells that overexpress HER-2/neu (HER2) and growth of some--but not all--that express low HER2. In HER2-overexpressing cells, suppression by E1A is predominantly by down-regulation of HER2, but the mechanism in low HER2-expressing c...
The aim of this work was to evaluate the stability of arsenic and selenium species retained in a lime/limestone mixture obtained by using limestone as a sorbent for gas cleaning in a coal gasification atmosphere. It was found that the stability of arsenic and selenium species produced by the gas-solid reactions with lime/limestone may be affected by their exposure to air and by their contact wi...
Diabetic nephropathy (DN) remains a major complication in both type 1 and type 2 diabetes. Systemic administration of antitransforming growth factor-beta (TGF-beta) antibody has shown some promise in mouse models of DN. However, chronic blockade of the multifunctional TGB-beta could be problematic. Several downstream effects of TGF-beta are mediated by connective tissue growth factor (CTGF), wh...
A 4-year-old girl with a history of a moderate-sized secundum atrial septal defect and mild mitral valve prolapse underwent transcatheter closure with a 22-mm Amplatzer septal occluder (ASO) (AGA Medical Corporation, Golden Valley, Minn) device. Approximately 12 months later, she presented to the emergency department in septic shock with a 5-day history of fevers up to 105°F and was transferred...
background: the late postoperative course for children with transposition of the great arteries (tga) with an intact ventricular septum (ivs) is very important because the coronary arteries may be at risk of damage during arterial switch operation (aso). we sought to investigate left ventricular function in patients with tga/ivs by echocardiography. methods: from march 2011 to december 2012, t...
Background The arterial Switch operation (ASO) is now performed routinely for the repair of transposition of the great arteries (TGA). Neo-aortic root dilatation and reduced elasticity of the ascending aorta have been shown to impact the long-term outcomes of these patients. The aim of this study was to assess the effect of the ASO with the Lecompte maneuver on the dynamic behavior and dimensio...
We investigate the combination of answer set programming and qualitative optimization techniques. Answer set optimization programs (ASO programs) have two parts. The generating program produces answer sets representing possible solutions. The preference program expresses user preferences. It induces a preference relation on the answer sets of based on the degree to which rules are satisfied. We...
Antisense oligonucleotides (ASOs) are recognized therapeutic agents for the modulation of specific genes at the post-transcriptional level. Similar to any medical drugs, there are opportunities to improve their efficacy and safety. Here we develop a short DNA/RNA heteroduplex oligonucleotide (HDO) with a structure different from double-stranded RNA used for short interfering RNA and single-stra...
Defence trees are used to represent attack and defence strategies in security scenarios; the aim in such scenarios is to select the best set of countermeasures that are able to stop all the vulnerabilities. In order to represent preferences among possible countermeasures of a given attack, defence trees are enriched with conditional preferences, obtaining a new structure called CP-defence tree....
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