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مقدمه: آسم بیماری التهابی مجاری تنفسی است که عوامل ژنتیکی و محیطی مختلفی در آن نقش دارند.بیماری آسم را از جنبه های ایمونولوژیک می توان مورد بررسی قرار داد. ژن های مختلفی از سیستم ایمنی در ایجاد و تشدید آسم دخیل هستند. از جمله این ژن ها در سیستم ایمنی خانواده tlrs می باشد.از انجا که ایجاد چندشکلی ژنی در ژنها باعث تغییر در نحوه پاسخ سیستم ایمنی می گردد در این مطالعه به بررسی چند شکلی ژنی در خانوا...
Despite significant advances in understanding the molecular basis of sepsis and its associated immunological response, sepsis remains a problem worldwide and is associated with a high mortality. Annually, septic shock, the most severe form of sepsis, causes the death of more than 100 000 people in the USA (3,4). Gram-negative bacteria are the most common pathogens associated with bacterial infe...
INTRODUCTION The objective was to investigate the potential implication of the IL18 gene promoter polymorphisms in the susceptibility to giant-cell arteritis (GCA). METHODS In total, 212 patients diagnosed with biopsy-proven GCA were included in this study. DNA from patients and matched controls was obtained from peripheral blood. Samples were genotyped for the IL18-137 G>C (rs187238), the IL...
A CUTE myocardial infarction and myocardial ischemia are leading causes of shortand long-term morbidity and mortality in the perioperative period. In part, this relates to the fact that treatment options for a myocardial infarction in surgical patients are extremely limited. For example, anticoagulation or treatment with highly effective inhibitors of platelet aggregation may not be an option d...
Immune responses contribute to the success of radiation therapy of solid tumors; however, the mechanism of triggering CD8 T cell responses is poorly understood. Antigen cross-presentation from tumor cells by dendritic cells (DC) is a likely dominant mechanism to achieve CD8 T cell stimulation. We established a crosspresentation model in prostate cancer in which DC present a naturally expressed ...
T he normal intestine encounters a high concentration of foreign antigen, bacteria, and food, across a large surface area that approximates to that of a tennis court. Despite the fact that this antigenic load is separated from the largest complement of lymphocytes in the body (gut associated lymphoid tissue, GALT) by only a single layer of polarised intestinal epithelium, most people do not mou...
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