نتایج جستجو برای: atm
تعداد نتایج: 13493 فیلتر نتایج به سال:
Double strand DNA breaks in the genome lead to the activation of the ataxia-telangiectasia mutated (ATM) kinase in a process that requires ATM autophosphorylation at serine-1981. ATM autophosphorylation only occurs if ATM is previously acetylated by Tip60. The activated ATM kinase phosphorylates proteins involved in arresting the cell cycle, including p53, and in repairing the DNA breaks. Chlor...
PURPOSE Mutations in the ATM (ataxia-telangiectasia mutated) gene, which encodes a 370 kd protein with a kinase catalytic domain, predisposes people to cancers, and these mutations are also linked to ataxia-telangiectasia (A-T). The histone acetylaion/deacetylation- dependent chromatin remodeling can activate the ATM kinase-mediated DNA damage signal pathway (in an accompanying work, Lee, 2007)...
Ataxia-telangiectasia and Li-Fraumeni syndrome, pleiotropic disorders caused by mutations in the genes atm and p53, share a marked increase in cancer rates. A number of studies have argued for an interaction between these two genes (for comprehensive reviews, see M. S. Meyn, Cancer Res., 55: 5991-6001, 1995, and M. F. Lavin and Y. Shiloh, Annu. Rev., Immunol., 15: 177-202, 1996). Specifically, ...
BACKGROUND Mutations in the DNA damage response (DDR) factors, breast cancer 1 (BRCA1) and BRCA2, sensitize tumor cells to poly(ADP-ribose) polymerase (PARP) inhibitors. The ataxia telangiectasia mutated (ATM) kinase is a key DDR protein whose heterozygous germline mutation is a moderate-risk factor for developing breast cancer. In this study, we examined whether ATM inactivation in breast canc...
PURPOSE In this study, we first sought to evaluate whether individuals heterozygous for ATM mutations may have an increased susceptibility to radiation-induced breast cancer (BC) after treatment for Hodgkin's disease (HD). We next sought to determine the frequency of ATM variants in patients with Hodgkin's lymphoma, regardless of coexisting BC, compared with healthy volunteers. EXPERIMENTAL D...
چکیده توسعه روزافزون جوامع بشری، گسترش سریع حمل و نقل هوایی را به دنبال داشته است. امروزه مدیریت ترافیک هوایی به مسئله پیچیده ای تبدیل گردیده که دانشمندان علاقه مند به حل آن می باشند. فشار زیاد کاری مراقبین پرواز، افزایش موقعیت های اضطراری پرواز، هواپیما ربایی، محدودیت فضای آزاد و غیر قابل پیش بینی بودن آن، نیاز به استقلال عمل، خودمختاری، اجازه دادن برای مسیر یابی و پیشگیری از تصادم را در مدیر...
Broadband and mobile communications are presently the two major drivers in the telecommunications industry. Asynchronous Transfer Mode (ATM) is considered the most suitable transport technique for the Broadband Integrated Services Digital Network (B-ISDN), due to its ability to flexibly support a wide range of services with Quality-of-Service (QoS) guarantees. These services are categorized in ...
complexity of the living cell is supported by the multitasking activity of its protein constituents. The kinase Ataxia Telangiectasia Mutated (ATM) is a clear example. Not only does it orchestrate the DNA damage response but also sustains cellular homeostasis, including metabolism, control of oxidative stress, autophagy and apoptosis [1]. Given its prevalent role in the cellular response to var...
The ATM serine-threonine kinase plays a central role in the cellular response to DNA damage. Germ-line mutations in the ATM gene cause ataxia-telangiectasia (A-T), a multisystem disorder associated with predisposition to lymphoma and acute leukemia. Moreover, somatic ATM mutations have been identified in T-cell prolymphocytic leukemia, mantle cell lymphoma, and B-cell chronic lymphocytic leukem...
The stem cell genomic stability forms the basis for robust tissue homeostasis, particularly in high-turnover tissues. For the genomic stability, DNA damage response (DDR) is essential. This study was focused on the role of two major DDR-related factors, ataxia telangiectasia-mutated (ATM) and ATM- and RAD3-related (ATR) kinases, in the maintenance of intestinal stem cells (ISCs) in the adultDro...
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