background: non- tuberculous mycobacteria are environmental opportunistic pathogens that can be found in various terrestrial and aquatic habitats. there are an epidemiological links between species isolated in tap water and those isolated from patients. hsp65 gene has more variability in its sequences, compared to the some more conserved genes in ntm, for identification of mycobacteria to speci...

several reports have indicated that infection with non-tuberculosis mycobacteria (ntm) is increasing worldwide.therefore,monitoring species causing micobacterial infection in any region is of great importance. this study was going to detect, differentiate, and identify pathogenic mycobacteria in primary clinical samples. eighty samples collected from tuberculosis suspected patients in isfahan/i...

Introduction Different terms are used to define non-tuberculosis mycobacteria [NTM] including atypical mycobarcteria and mycobacteria other than tuberculosis [MOTT]. However, NTM terminology is the most used name worldwide. NTM, an emerging entity, includes more than 100 species with variable microbiological features, clinical manifestations and significances. Nevertheless, NTM therapy also dif...

Nontuberculous mycobacteria are ubiquitous and saprophytic organisms that have been implicated in a wide spectrum of diseases due to an increasing number of immunocompromised patients. The natural resistance of atypical mycobacteria to classical antituberculous drugs has encouraged research into new chemotherapeutic agents and drug combinations. The aim of this study was to determine the in vit...

SUMMARY Tuberculosis (TB) in elephants has the potential to infect humans and is an increasing public health concern. Lao PDR is one of the last countries where elephants are still used for timber extraction and where they live in close contact with their mahouts. There are 500 animals at work in the country, some interacting with wild herds. Although human TB prevalence is known to be high in ...

A probe based on 16S ribosomal RNA (rRNA) sequences was developed to detect Mycobacterium paratuberculosis, the causative agent of Johne's disease in cattle. Three universal primers were used to sequence the amplified fragments of the 16S rRNA gene of various species of mycobacteria. When the nucleotide sequences were analysed, a deletion was detected in the sequence of the fast-growing species...

Tuberculosis and leprosy are two well known mankind diseases that are caused by members of the genus Mycobacterium. When originally named in 1896, this genus contained the leprosy bacillus (Mycobacterium leprae) observed by Armour Hansen in 1874 and the tubercle bacillus (Mycobacterium tuberculosis) observed and cultured by Robert Koch in 1882. As time went by, other bacilli similar to those of...

Infections due to non-tuberculous mycobacteria species are problematic for immunodeficient individuals. Mendelian susceptibility to mycobacterial diseases (MSMD) defines a group of genetic defects affecting cellular interactions and the interferon (IFN)-γ pathway. Patients with MSMD may present with a disseminated infection resulting from the Bacillus Calmette-Guerin vaccine, Mycobacterium tube...

In Japan, the rate of pulmonary nontuberculous mycobacteriosis (NTM) (atypical mycobacterial diseases) in the total pulmonary mycobacteriosis is continously increasing, in 1994 it reached 14.0% in newly admitted mycobacteriosis cases in 211 sanatoriums throughout Japan (1), and NTMbecame considered an important chest disease. This increase is mainly dependent uponthe recent rapid decrease of tu...

Nontuberculous mycobacteria are ubiquitous and saprophytic organisms that have been implicated in a wide spectrum of diseases due to an increasing number of immunocompromised patients. The natural resistance of atypical mycobacteria to classical antituberculous drugs has encouraged research into new chemotherapeutic agents and drug combinations. The aim of this study was to determine the in vit...