Here, we report a rare case of systemic lupus erythematosus (SLE) with conspicuous manifestation of hematological abnormalities. At onset, the 52-year-old male patient showed systemic lymphadenopathy and splenomegaly, severe autoimmune thrombocytopenia, and autoimmune neutropenia. Bone marrow examination and lymph node biopsy excluded the possibility of malignant lymphoma. Based on laboratory f...

Lymphoproliferative disorder (LPD) is a severe adverse outcome of methotrexate (MTX) administration in patients with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). The immunosuppression caused attributed to pathogenesis. Hence, discontinuation the treatment. Reports on spontaneous tumor lysis cessation MTX are rare. We report case female her 50s methotrexate-associated lympho...

Autoimmune lymphoproliferative syndrome (ALPS) is a rare disorder of disrupted lymphocyte homeostasis. Clinical manifestations of ALPS vary but typically include autoimmune cytopenias, organomegaly, lymphadenopathy, and increased risk of malignancies. A similar spectrum of symptoms may be seen in some patients with Evans syndrome (ES), a hematologic disorder defined by autoimmune destruction of...

The clinical course of viral hepatitis can get complicated by a myriad of rheumatic symptoms which can alter the management strategies and have a profound potential to impair the quality of life of the patient. Rheumatic complications are often seen with hepatitis B (HBV) and hepatitis C (HCV) virus infections. The mechanism of these rheumatic complications seems to be immune mediated. Chronic ...