نتایج جستجو برای: autoimmune myositis
تعداد نتایج: 69470 فیلتر نتایج به سال:
Objective: To describe the use of large-scale gene expression profiles to distinguish broad categories of myopathy and subtypes of inflammatory myopathies (IM) and to provide insight into the pathogenesis of inclusion body myositis (IBM), polymyositis, and dermatomyositis. Methods: Using Affymetrix GeneChip microarrays, the authors measured the simultaneous expression of approximately 10,000 ge...
PURPOSE OF REVIEW Inclusion body myositis (IBM) is an enigmatic progressive disease of skeletal muscle. This review provides a summary of the clinical and pathophysiologic aspects of IBM. RECENT FINDINGS The development of diagnostic blood testing for IBM followed from the discovery of a B-cell pathway in IBM muscle and circulating autoantibodies against NT5C1A, further establishing IBM's sta...
Background: Immunoblot assays are increasingly used in clinical practice as part of the diagnostic armamentarium systemic autoimmune rheumatic diseases (SARDs). Objectives: To assess contribution an extended scleroderma/myositis-related antibodies (Ab) determination by immunoblot to diagnosis patients with SARDs. Methods: We reviewed all medical records positive Ab line blot determinations (Eur...
Background Recent data showed that SARS-CoV-2 infection and vaccination could act as a trigger for different autoimmune diseases, including idiopathic inflammatory myopathies (IIM). Objectives The aim of this study was to describe the clinical characteristics patients diagnosed with IIM following in tertiary rheumatology center. Methods We conducted retrospective analysis on newly IIM, from 1 J...
In this case, we describe an unusual presentation of a young woman with a rash typical of morphoea (confirmed on biopsy), who went on to develop myositis in an atypical distribution. Although the association of myositis with diffuse systemic sclerosis is well described, the link with localised scleroderma (morphoea) and myositis has not been described.
A 69 year old woman with inclusion body myositis is described. She presented with benign monoclonal gammopathy. She was resistant to steroid therapy, but responded to repeated immunoabsorption. Up to now, there has been no established therapy for inclusion body myositis, including IVIg. It is suggested that immunoabsorption could be an alternative therapy for inclusion body myositis, when it wa...
BACKGROUND Interstitial lung disease (ILD) is a prognostic indicator of poor outcome in myositis. Although the pathogenesis of myositis-associated ILD is not well understood, neutrophils are thought to play a pivotal role. Neutrophils store azurophil granules that contain defensins, which are antimicrobial peptides that regulate the inflammatory response. Here, we evaluated levels of the human ...
Sjogren’s syndrome (SS) is a chronic autoimmune disease characterized by the lymphocytic infiltration of exocrine glands, mainly the salivary and lachrymal glands entailing the classical sicca syndrome of xerostomia (Sjögren, 1933) and xeropthalmia. Lymphocytic infiltration of other organs results in systemic manifestations. SS is classified as either primary (pSS), when occurring alone, or sec...
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