Summary: MVP-Fit is a visualization tool for interactive fitting atomic protein domain structures with the cryo-Electron Microscopy density map. To achieve the best match, the program can conveniently adjust the loop and tail outliers of individual domains to accommodate the local conformational changes from the rigid-body rotation and translation of protein domains. Availability: The MVP-Fit p...

The question often arises of whether or not a given security system requires some form of automated key management, or whether manual keying is sufficient. This memo proposes guidelines for making such decisions. The presumption is that when symmetric cryptographic mechanisms are used in a protocol, then automated key management is generally but not always needed. If manual keying is proposed, ...

Computer assisted surgical planning and image guided technology have become increasingly used in neurosurgery. We have developed a system based on ATmC (Adaptive Template moderated Classification) for the automated segmentation of 3D MRI brain data sets of patients with brain tumors (meningiomas and low grade gliomas) into the skin, the brain, the ventricles and the tumor. In a validation study...

Manual and automated methods for the determination of blood glucose have been devised using an oxidase/peroxidase system, with dl adrenaline, a non-carcinogen, as oxygen acceptor. The manual technique employs a stable single solution protein precipitant and the other reagents used are also stable. The automated methods are operated at 40/hr sample speed and washover between samples, over a very...

To the Editor: Myers et al.1 in their article “Comparison Between an Automated and Manual Sphygmomanometer in a Population Survey” compared blood pressures (BPs) measured with a standard mercury sphygmomanometer and an oscillometric sphygmomanometer and concluded that “conventional manual BP readings taken using mercury sphygmomanometry can be replaced by (readings taken using) a validated, aut...

Received, June 28, 2002. Accepted, October 18, 2002. OBJECTIVE: Programmable, multicontact, implanted stimulation devices represent an important advance in spinal cord stimulation for the management of pain. They facilitate the technical goal of covering areas of pain by stimulation-evoked paresthesiae. Adjustment after implantation requires major investments of time and effort, however, if the...

The question often arises of whether or not a given security system requires some form of automated key management, or whether manual keying is sufficient. This memo proposes guidelines for making such decisions. The presumption is that when symmetric cryptographic mechanisms are used in a protocol, then automated key management is generally but not always needed. If manual keying is proposed, ...

We demonstrate an automated segmentation method for in-vivo 3D optical coherence tomography (OCT) imaging of the lamina cribrosa (LC). Manual segmentations of coronal slices of the LC were used as a gold standard in parameter selection and evaluation of the automated technique. The method was validated using two prototype OCT devices; each had a subject cohort including both healthy and glaucom...

In five patients with mesial temporal sclerosis, the authors verified the precision and reproducibility of hippocampal segmentations with deformation-based magnetic resonance (MR) imaging. The overall percentage overlap between automated segmentations was 92.8% (SD, 3.5%), between manual segmentations was 73.1% (SD, 9.5%), and between automated and manual segmentations was 74.8% (SD, 10.3%). De...

The assumptions underlying security policy models, such as the Bell-LaPadula model, are usually not explicitly stated. This has led to several common misconceptions about this model and its scope. A comparison of manual and automated systems is used to demonstrate the derivation of the Bell-LaPadula ?property (pronounced star-property) for automated systems and its analog for manual systems. Th...