Transcranial Doppler sonography allows for noninvasive assessment of dynamic cerebral autoregulation. A wider clinical use of this approach has been hampered by the need for continuous arterial blood pressure (ABP) measurements. We describe a new method of a pure Doppler signal based estimation of dynamic autoregulation using heart rate (HR) and cerebral blood flow velocity (CBFV) information. ...

The effect of several agents active on autonomic nervous system functions was tested on brain oxygen autoregulation parameters. It was found that atropine, propranolol and isoproterenol had no influence in abolishing the measured parameters. Phenoxybenzamine, tolazoline and dibenamine all suppress autoregulation. In an additional experimental series, a phenoxybenzamine infusion was given during...

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