Awake craniotomy is still in its evolutionary stage and is generally successful in a highly motivated patient. The attending anesthesiologist must ensure that patient is optimally sedated and pain free yet readily arousable. In addition, it is essential to have a Plan B and C ready in case the first one fails. We adopted awake craniotomy technique in a 33 yr old male patient undergoing excision...

Neuroreceptor Imaging of the Awake Nonhuman Primate Christine Marie Sandiego 2013 Measuring dynamic changes in neurotransmitter systems with positron emission tomography (PET) can provide insight on dysfunction in neurotransmission that gives rise to central nervous system disorders. Studies in the nonhuman primate (NHP) are valuable for guiding translational research approaches for human studi...

Extracorporeal membrane oxygenation (ECMO) has been used in an increasing number of centers as a bridge to lung transplant.1-4 It is recognized that as the lungs fail, invasive mechanical ventilation may not fulfill the optimal goals as a bridge to transplant. There have now been several international reports of ECMO as a successful bridge to transplant in patients who are awake and non-ventila...

OBJECTIVE To compare the quality and accuracy of manual office blood pressure and automated office blood pressure using the awake ambulatory blood pressure as a gold standard. DESIGN Multi-site cluster randomised controlled trial. SETTING Primary care practices in five cities in eastern Canada. PARTICIPANTS 555 patients with systolic hypertension and no serious comorbidities under the car...

Disrupting the reactivation of hippocampal neurons during sleep impairs memory consolidation in rats. However, the functional importance of reactivation during awake states is unknown. An experiment in which awake reactivation was disrupted suggests that this phenomenon could adaptively guide behavior by linking previous learning with the current state of the world.

Responses to sound in the auditory cortex are influenced by the preceding history of firing. We studied the time course of auditory adaptation in primary auditory cortex (A1) from awake, freely moving rats. Two identical stimuli were delivered with different intervals ranging from 50 ms to 8 s. Single neuron recordings in the awake animal revealed that the response to a sound is influenced by s...

The co-occurrence of primary brain tumor and pregnancy poses unique challenges to the treating physician. If a rapidly growing lesion causes life-threatening mass effect, craniotomy for tumor debulking becomes urgent. The choice between awake craniotomy versus general anesthesia becomes complicated if the tumor is encroaching on eloquent brain because considerations pertinent to both patient sa...

BACKGROUND To determine whether automated office blood pressure (AOBP) readings are associated with left ventricular mass (LVM) index as closely as those of 24-h ambulatory blood pressure (ABP) and also to confirm that the values of the two methods are comparable in the appraisal of blood pressure in a European population referred for suspected hypertension. METHODS In a sample of 90 individu...

Awake surgery could be a useful modality for lesions locating in close proximity to the eloquent areas including primary motor cortex and pyramidal tract. In case with supplementary motor area (SMA) lesion, we often encounter with intraoperative motor symptoms during awake surgery even in area without positive mapping. Although the usual recovery of the SMA syndrome has been well documented, ra...

For many songbirds, the vocal repertoire comprises acoustically distinct songs that are flexibly used in various behavioral contexts. To investigate how these different vocalizations are represented in the song neural system, we presented multiple song stimuli while performing extracellular recording in nucleus HVC in adult male song sparrows Melospiza melodia, a species known for its complex v...