A novel nitrogen-doped corannulene derivative, 8-tert-butyl-6b(2) -azapentabenzo[bc,ef,hi,kl,no]corannulene, was synthesized by 1,3-dipolar cycloaddition of a polycyclic aromatic azomethine ylide with a diarylethyne and subsequent palladium-catalyzed intramolecular cyclization. This molecule represents the first example of a corannulene derivative bearing an internal heteroatom, and exhibits un...

The title compound, C(12)H(10)N(4)O, is a Schiff base obtained from the condensation of diamino-maleonitrile and 2-hy-droxy-3-methyl-benzaldehyde. The mol-ecule is roughly planar, with an r.m.s. deviation of 0.0354 Å, and adopts the phenol-imine tautomeric form. An intra-molecular O-H⋯N hydrogen bond involving the O-H group and the azomethine N atom generates an S(6) ring. In the crystal, there...

For the first time, arylmethylidene cyclohexanones that are non-symmetrical due to the presence of peripheral substituents were studied in 1,3-dipolar cycloaddition reactions. It is shown that the interaction with the azomethine ylide generated from sarcosine proceeds regio- and diastereoselectively, with the participation of two non-equivalent parts of the dipolarophile. Also for the first tim...

A series of eight new azomethine derivatives were synthesized by reacting 2-formylphenoxyacetic acid with aromatic amines. The chemical structures of these compounds were confirmed by means of 1H-NMR, 13C-NMR, MS and elemental analysis. The compounds were assayed by the disc diffusion method for antibacterial against Staphylococcus aureus and Escherichia coli. Among the compounds tested, 2a, 2b...

The five-membed ring of the title compound, C(11)H(13)NO, that is fused with the aromatic ring is approximately planar (r.m.s. deviation = 0.037 Å) despite the presence of the sp(3)-hybrid-ized ethyl-ene linkage. The hy-droxy group of the N-bound hy-droxy-ethyl chain serves as hydrogen-bond donor to the azomethine N atom of an adjacent mol-ecule, generating a hydrogen-bonded C(2)-symmetric dimer.

A facile and efficient one-pot synthesis of pyrrolidines and dispiro pyrrolidines/pyrrolizidines has been accomplished by the 1,3-dipolar cycloaddtion reaction of azomethine ylides generated insitu from paraformaldehyde/ninhydrin and secondary amino acids with electron-deficient dipolarophiles in good yield. The reaction proceeded with high regio and stereoselectivity. The products have been ch...

Schiff bases are aldehyde or ketone like compounds in which the carbonyl group is replaced by an imine or azomethine group. They are widely used for industrial purposes and also exhibit a broad range of biological activities. The reaction is acid catalysed, however only aldehydes and ketones which do not aldolize easily in acidic media, can be condensed with amines in presence of strong acid ca...

In the title compound, [Co(C(9)H(8)Br(2)NO)(2)], the Co(II) atom, located on a twofold axis, is in a pseudo-tetra-hedral environment, with two bidentate 2,4-dibromo-6-(ethyl-imino-meth-yl)phenolate Schiff base ligands acting as chelates through their phenolate O and azomethine N atoms. C-H⋯O hydrogen bonds link the complex mol-ecules to form a chain parallel to the b axis.

1,3-Dipolar cycloaddition of azomethine ylides derived from acenaphthylene-1,2-dione and 5methyl-benzo[b]-thiophene-2,3-dione with L-proline, thiazolidine-4-carboxylic acid and 1,2,3,4tetrahydroisoquinoline-3-carboxylic acid with various electron deficient dipolarophiles leads to the formation of novel spiroheterocycles having two or more chiral centers. Semiempirical studies have been performe...

We developed a 1,3-dipolar cycloaddition reaction of azomethine imines with terminal alkynes catalyzed by group 11 metal amides to provide N,N-bicyclic pyrazolidinone derivatives. This reaction afforded the cycloadducts in a unique 5,7-disubstituted manner. Furthermore, we succeeded in applying this catalysis to asymmetric reactions, and the desired heterocycles were produced in high yields wit...