Balanced chromosomal translocations in men can cause failure of spermatogenesis owing to meiotic impairment. Male carriers may exhibit normozoospermia, although clinical manifestations can include oligozoospermia or azoospermia, oligozoospermia or normozoospermia. Here, we reported the characteristics of balanced reciprocal translocations in men from northeastern China, and explored the relatio...

Men with severe oligospermia (<5 million sperm/mL ejaculate fluid) or azoospermia should receive genetic testing to clarify etiology of male infertility prior to treatment. Categorization by obstructive azoospermia (OA) or non-obstructive azoospermia (NOA) is critical since genetic testing differs for the former with normal testicular function, testicular volume (~20 mL), and follicle-stimulati...

BACKGROUND In the recent years, the use of laboratory blood factors such as FSH and inhibin-B for the assessment of spermatogenesis in different studies has increased; of course, the conflicting results have also been achieved. OBJECTIVE To investigate if the measurement of inhibin-B can help surgeon to reduce unnecessary diagnostic testicular biopsies in males with azoospermia. MATERIALS A...

BACKGROUND Suppression of spermatogenesis to azoospermia is required for effective hormonal male contraception, but the degree of suppression varies between ethnic groups. We here report the first study of hormonal suppression of spermatogenesis in two African centres using a regimen of oral progestogen with depot testosterone. METHODS A total of 31 healthy men (21 black) were recruited in Cape...

Infertility is defined as the inability to conceive after 1 year of regular unprotected sexual intercourse. About 15% of couples are affected. Male factors account for about 50% of couples with infertility.1 Approximately 10 to 15% of infertile men suffer from azoospermia—complete absence of sperms in the ejaculate. Among these azoospermic patients, approximately 40% have complete obstruction i...

Due to its palindromic setup, AZFc (Azoospermia Factor c) region of chromosome Y is one of the most unstable regions of the human genome. It contains eight gene families expressed mainly in the testes. Several types of rearrangement resulting in changes in the cumulative copy number of the gene families were reported to be associated with diseases such as male infertility and testicular germ ce...

sit together, rather uncomfortably, in the same category, and Assisted Conception Services, Birmingham Women’s Hospital, is a recipe for potential misdiagnosis and mismanagement. Birmingham B15 2TG, UK It is a truism that one needs to appreciate the normal in This opinion was previously published on Webtrack 93, order to understand the abnormal. Normally, the hormones of November 4, 1999 the hy...

OBJECTIVE Histological testicular pattern has a predictive role in the possibility of finding spermatozoa for ICSI in cases of non-obstructive azoospermia because some individuals could show residual spermatogenic sites in the testis. The aim of this study was to evaluate the sperm retrieval rate in each of the histopathological groups (hypospermatogenesis--Hypo, spermatogenic maturation arrest...

Objective – To study the incidence of male factor infertility and type of semen abnormality in the farmer couple attending our infertility outpatient clinic. MethodDatabase of 3100 patients with male factor infertility were retrospectively reviewed. Patients were divided in two groups for analysis: group 1 – farmer , group 2 – non farmer. Records of semen analysis and serum FSH (Follicle stimul...

Surgical sperm retrieval through percutaneous epididymal aspiration was used to manage effectively unexpected obstructive azoospermia on the day of oocyte retrieval.